Can we predict and prevent weight gain in early psychosis?

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New research suggests that weight gained in the first 12 weeks of antipsychotic treatment is the biggest driver of long-term obesity in psychosis.

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Metformin reduces weight gain in young people taking antipsychotics

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Large pragmatic trial found metformin plus lifestyle intervention reduced weight gain in young people with bipolar disorder taking antipsychotics. Effect significant but modest at 6 and 24 months.

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Coercive control and intimidation: stronger links to adult mental health than physical violence

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Non-physical domestic violence (intimidation, control, property damage) in childhood showed stronger associations with adult mental health disorders than physical violence in large Australian study.

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Rapid weight gain after SMI diagnosis, but why so few referrals for support?

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A 15-year analysis of UK primary care records showed steep and sustained weight gain after an SMI diagnosis, especially among younger adults and people prescribed antipsychotic medication. Yet very few received referrals for weight-management support, raising important questions about practice and policy.

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How common are eating disorders in adults seeking obesity treatment?

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Most of what we know about eating disorders in adults with obesity focuses on binge eating. But what about everything else? This new systematic review pulls together data from 94,000 adults to estimate how common different eating disorders and disordered eating behaviours really are among people seeking obesity treatment.

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Is it a gut feeling? How the microbiome may shape perinatal mental health in women with higher body weight

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What if perinatal mental health started in the gut? New research from Finland suggests certain bacteria may be associated with depressive and anxiety symptoms during pregnancy and after birth, raising questions about inflammation, causality, and the future of microbiome-based screening and treatment.

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GLP-1 receptor agonists and the brain: could these medications boost more than metabolism?

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GLP1 drugs are already used to treat diabetes and support weight loss, but do they have any impact on mental health? This new meta-analysis looks at the evidence from 80 clinical trials.

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Are dementia prevalence and incidence declining? Findings from a review of cohort studies

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Clarissa Giebel summarises a recent review global cohort studies, which asks the question – is dementia on the downturn, and are the risks the same in high-income or low to middle income countries?

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Body weight and perinatal depression: what’s the link?

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In her debut blog, Sarah Nicholson summarises a systematic review of pre-pregnancy BMI and the risk of antenatal and postnatal depression.

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Critiquing the evidence behind the “evidence-based conclusions” about ADHD

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Shuichi Suetani and Gaj Panagoda explore the World Federation of ADHD International Consensus Statement published in 2021, which contains “208 evidence-based conclusions about attention-deficit hyperactivity disorder.

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