Oral Cancer: Elective neck dissection or watch and wait?

Bariatric surgery and marked weight loss is likely to improve knee complaints but there is a need for high quality studies

There is an ongoing debate about the management of patients with oral cavity squamous cell carcinoma and clinically negative cervical lymph nodes. Some clinicians favour preventive elective neck dissection (END) which although is linked with favourable survival has an adverse effect on quality of life while others adopt a wait and watch policy. The aim [read the full story…]

Oral mucositis in cancer patients: the effect of oral supplementation

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This review of of the effects of oral supplementation on the prevention and/or treatment of oral mucositis in patients with cancer undergoing chemotherapy and/or radiotherapy included 12 RCTs and suggest that Zinc supplements may be beneficial.

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Mucositis in adult cancer patients reduced with keratinocyte growth factor

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This Cochrane review of cytokines and growth factors for preventing oral mucositis in patients having cancer treatment included 35 RCTs finding keratinocyte growth factor beneficial in the prevention of oral mucositis .

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Oral mucositis in cancer patients: no benefit from chlorhexidine mouthwash

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This review of chlorhexidine (CHX) for prevention & treatment of oral mucositis included 12 RCTs with 9 contribution to the meta-analysis. CHX was not significantly effective in preventing mucositis or reducing its severity.

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Antidepressants for depression in cancer: Cochrane review highlights lack of evidence

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Kirsten Lawson reports on a recent Cochrane systematic review, which highlights a lack of high quality trials about the efficacy and safety of antidepressants for depression in cancer.

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Psychological support needed across cancer pathway

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In this blog, Alison Turner takes a look at guidance, which sets out recommendations for commissioners and providers to improve care and outcomes for people with cancer.

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Premature mortality in bipolar disorder

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Elena Marcus appraises a recent systematic review and meta-analysis of premature mortality in bipolar affective disorder, which finds that people with bipolar disorder have increased mortality rates compared with the general population.

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Alcohol consumption increased oral cancer risk

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This new review investigated the effect of alcohol on 23 cancer types. They included 572 case-control and cohort studies and using meta-analysis and a dose–response meta-regression model found relative risks for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer.

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Depression and cancer: Lancet papers on prevalence and integrated collaborative care

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Kirsten Lawson highlights a trio of Lancet papers on the prevalence of depression in cancer patients and the efficacy of a new treatment programme called ‘Depression Care for People with Cancer’.

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