The optimal state of the mouth and normal functioning of the organs of the mouth without evidence of disease.
Fluoride varnish for prevention of white spot lesions during orthodontic treatment

This review evaluating the preventive effect of regular applications of fluoride varnish (FV) on the development of white spot lesions (WSL) during orthodontic treatment included 7 RCTs. Meta-analyses demonstrated a reduction in the risk of WSL with regular FV applications but the certainty of evidence was very low.
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