Articaine: Safety and efficacy compared to lidocaine

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This review assessing the safety and efficacy of articaine for routine dental treatment compared to lidocaine included 12 RCTs involving a total of 919 patients. The findings indicate that articaine is is a safe and efficacious local anaesthetic for all routine dental procedures.

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Intraoral stents to reduce oral toxicity of radiotherapy

Varian TruBeam Linear Accelerator, Rathiotherapy

This review assessing the effectiveness of intraoral stents in reducing toxicities in oral cavity induced by radiotherapy in head and neck region included 7 small studies. While the analysis suggests a beneficial effect from the use of intraoral stents the included studies only provide verylow certainty evidence so further high-quality RCTs are needed.

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Antidepressants and psychotherapy for adolescent depression: can they be compared? #ActiveIngredientsMH

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Catherine Harmer summarises a recent network meta-analysis relating to her own Wellcome Trust funded research into antidepressants for young people with anxiety or depression.

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Third molars: Which local anaesthetic is most suitable for inferior alveolar nerve blocks?

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This review comparing the efficacy and safety of currently available local anaesthetics for lower third molar extraction included 24 RCTs. The findings suggest that 4% articaine was the most effective and lidocaine the safest.

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Problematic smartphone use: what are the consequences for teens and their screens?

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Lucinda Powell explores a recent systematic review and meta-analysis which finds that problematic smartphone use in young people is associated with poorer mental health.

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Are antidepressants safe? A new umbrella review of observational studies suggests they are, but we need more accurate data

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Andrea Cipriani and Anneka Tomlinson scrutinise a brand new umbrella review of the associations between antidepressants and adverse health outcomes, which suggests that antidepressants are safe for most people who experience mental health difficulties.

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Is too much screen time bad for our children? Perhaps, but how much do we really know?

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David Turgoose explores a systematic review of reviews that looks at the effects of screen time on the health and well-being of children and adolescents. The review found that higher levels of screen time were related to some physical and mental health concerns, such as poor diet, obesity and depression.

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Silver diamine fluoride for caries management?

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This umbrella review of silver diamine fluoride (SDF) for the management of carious lesions in children and adults included 11 systematic reviews reporting on 30 unique primary studies. A consistent and growing body of research supports supports SDF’s effectiveness for arresting coronal carious lesions in the primary dentition and arresting and preventing root carious lesions in older adults.

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Higher doses of antidepressants “not optimal”, according to new review

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Jonathon Tomlinson considers his options as a GP supporting people with depression and complex needs, after reading a new systematic review and dose-response meta-analysis, which suggests that higher doses of antidepressants bring maximum side effects with only marginal gains.

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Antidepressants and weight gain: long-term population impact #SUSANAsurvey

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Andrea Cipriani and Anneka Tomlinson summarise a 10-year cohort study of antidepressant use and incidence of weight gain.

They also launch their new SUSANA project: Survey for Understanding Side effects of ANtidepressants in Adults. Please take the SUSANA survey now!

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