A major new RCT of Structured Psychological Support finds brief therapy offers no meaningful benefit over usual care for people with personality disorders.
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We have the evidence that lifestyle interventions work. Now what? The third Lancet Psychiatry Commission focuses on the messy business of implementation.
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Systematic review of 54 RCTs found limited evidence for cannabinoids treating mental health conditions. Most robust findings for cannabis use disorder, but overall quality low.
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Large pragmatic trial found metformin plus lifestyle intervention reduced weight gain in young people with bipolar disorder taking antipsychotics. Effect significant but modest at 6 and 24 months.
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Systematic review of 60 studies found personality disorders affect 5.2% in high-income countries, associated with elevated mortality, yet excluded from global disease burden estimates.
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This Finnish study of 5,834 healthcare records found therapist-guided internet CBT showed similar depression improvements to face-to-face therapy, providing real-world evidence beyond selective RCT populations.
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This Danish study of over 3 million people found that having a first-degree relative with depression increased risk 2.35-times, resulting in 15% lifetime risk (compared to 7.8% in the general population). However, 60% of depression cases occurred in people with no affected close relatives, highlighting that family history is only part of the story.
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This twin study of nearly 14,000 UK adolescents found that body dissatisfaction at age 16 was linked to eating disorder symptoms at 21 and depression at 26. Comparing twins helped researchers show these were likely causal relationships, not just correlations, though genetics also played a substantial role.
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This network meta-analysis of 76 trials found that slow tapering (over 4 weeks) combined with psychological support was most effective for preventing relapse when stopping antidepressants. Abrupt discontinuation and fast tapering substantially increased relapse risk and should be avoided.
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A 15-year analysis of UK primary care records showed steep and sustained weight gain after an SMI diagnosis, especially among younger adults and people prescribed antipsychotic medication. Yet very few received referrals for weight-management support, raising important questions about practice and policy.
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