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Occlusal caries prevention: Seal or varnish?

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This large, well-conducted study in a primary care setting found a small, but not statistically significant difference, between fissure sealants and fluoride varnish for the prevention of caries in first permanent molars at 36 months.

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Depression in later life: who benefits most from antidepressants plus exercise?

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Linda Gask explores an RCT of physical exercise for depression in later life, which considers the best way to customise the intervention for primary care.

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Probiotics for depression: robust and compelling evidence?

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A team from the Centre for Affective Disorders at King’s College London appraise a new systematic review on probiotics for depression, which claims to have found robust and compelling evidence that these supplements can alleviate depressive symptoms.

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The stigma of eating disorders: which interventions might help?

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Francesca Solmi summarises a new systematic review of stigma and eating disorders, and asks if it’s time to move beyond socio-cultural explanations of risk.

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CBT may help reduce anxiety and depression in people with diabetes, but standardised approach needed

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Ben Perry explores the findings of a recent systematic review looking at the effectiveness of cognitive-behavioural therapy on glycaemic control and psychological outcomes in adults with diabetes.

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Psychotherapies for borderline personality disorder: DBT and psychodynamic approaches do best

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Andrew Shepherd summarises a recent meta-analysis on the efficacy of psychotherapies for borderline personality disorder, which finds that dialectical behaviour therapy and psychodynamic approaches were effective versus control, but CBT and other talking treatments were not.

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Life expectancy in schizophrenia and years of potential life lost

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Joanne Wallace summarises a recent systematic review and meta-analysis that reinforces the urgent call for better interventions to address the causes of premature death in schizophrenia.

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Exercise and iCBT for depression: how do ‘alternative’ treatments compare to usual care?

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Bethan Davies publishes her debut blog on a recent Swedish RCT of exercise and internet-based cognitive-behavioural therapy for depression.

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‘All-on-4®’ treatment concept: current evidence limited

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This systematic review of the ‘All-on-4®’ concept for fixed full arch restoration includes 24 studies of limited quality is considered here by Mark-Steven Howe.

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Personality disorders and alcohol treatment: is there any hope?

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Ian Hamilton and Kelly Davies provide some optimism after reading a new systematic review about personality disorders and alcohol treatment outcomes.

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