Is depression a cause or consequence? Using genetics to untangle causal relationships

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This study used Mendelian randomisation to test potential causal relationships between depression and 137 traits. Depression liability was linked to somatic diseases, inflammation, suicide risk, insomnia, lower cognitive function and functional impairments, though findings require validation.

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Weighing the risks: new review ranks antidepressants by their physical health side effects

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Antidepressants can help millions of people recover from depression and anxiety, but how do they affect physical health? Out today, a review in The Lancet compared 30 antidepressants to see which ones are most (and least) likely to increase our risk of heart disease, stroke, diabetes etc.

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Painting prevention: How the arts promote health and tackle non-communicable diseases

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Non-communicable diseases cause 74% of global deaths. Could singing, dancing or storytelling really make a difference? This new review explores how arts-based interventions can boost public health worldwide.

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Do psychiatric disorder genes overlap with their drug targets? And does this matter?

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Psychiatric disorders are highly heritable, but are the genes we identify in GWAS the same ones our medications target? This new study digs into the overlap and raises questions about how we develop treatments.

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GLP-1 receptor agonists and the brain: could these medications boost more than metabolism?

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GLP1 drugs are already used to treat diabetes and support weight loss, but do they have any impact on mental health? This new meta-analysis looks at the evidence from 80 clinical trials.

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Tuberculosis and depression: multimorbidities are a global health challenge

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A team of experts from the Global NIHR Centre for IMPACT consider the findings of a recent meta review, which looks at the prevalence and risks of tuberculosis multimorbidity in low-income and middle-income countries.

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Finding balance: managing diabetes and depression with physical activity

The therapeutic alliance benefited from a flexible combination of suicide risk assessment and therapeutic conversations.

Aliya Ayub explores a systematic review and meta-analysis on the effectiveness of physical activity interventions for the management of depression symptoms and glycaemic control in people with depression and type 2 diabetes.

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Genetic risk for Tourette Syndrome and related conditions

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Ed Palmer considers new research on the genetic risk for Tourette Syndrome and it’s relationship to other mental and physical health conditions.

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Edentulism in diabetics compared to non-diabetics

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This review of the prevalence of edentulism among diabetic patients compared to non-diabetic people included 7 cross-sectional studies. The findings suggest a higher level of edentulism in diabetic patients but the findings should be interpreted cautiously.

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Caries experience in patients with diabetes mellitus

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This review of caries experience in adult patients with diabetes mellitus (DM) compared diabetics to individuals without DM included 13 mainly cross-sectional studies. The findings suggest higher DMF scores in patietns with DM.

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