The diagnosis dilemma: can transdiagnostic approaches close the care gap for distressed youth?

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Many young people are clearly struggling but don’t fit any diagnosis. A new meta-analysis asks whether transdiagnostic support can help them before a label arrives.
Transdiagnostic interventions show small but consistent gains.

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What works in domestic abuse and sexual violence services? Encouraging signals, fragmented evidence, and an urgent measurement problem

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Services for domestic abuse and sexual violence are widely delivered and highly valued, but how confident can we be that they work? A new UK-focused systematic review of what the evidence actually shows.

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Can experiencing mental illness literally cause heartache?

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A systematic review of 22 million people finds several mental health conditions, including PTSD, depression and anxiety, are linked to higher acute coronary syndrome risk.

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Brief interventions after suicide attempts: does connection save lives?

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Fifty years after Jerome Motto’s caring letters, this meta-analysis suggests brief interventions can help people through the high-risk period after a suicide attempt. However, we still don’t know how they work.

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CBT for depression in primary care: gold standard, or one option among many?

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Does CBT really outperform other treatments for depression in primary care settings? A recent systematic review suggests patients may have more options than we think.

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Trauma-focused therapy for psychosis: helpful for delusions, less so for hallucinations

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A new meta-analysis from Toutountzidis and colleagues finds trauma-focused therapies meaningfully reduce delusions in psychosis, but offer limited benefit for hallucinations. Younger people gain most.

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In the Land of the Unblind: are psychedelics really better than antidepressants?

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Psychedelic therapy looks impressive in trials, but when you account for the placebo effect, how does it really compare to antidepressants?

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Can You ‘Catch’ Suicide? What This Meta-Analysis Really Tells Us

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If your friend is struggling with suicidal thoughts, are you at greater risk? A meta-analysis of over 1 million people explores the evidence.

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Medical cannabinoids as a treatment for mental health: helpful or hazardous?

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Systematic review of 54 RCTs found limited evidence for cannabinoids treating mental health conditions. Most robust findings for cannabis use disorder, but overall quality low.

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People in prison face disproportionate mental and physical illness

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Umbrella review of global prison populations finds 40% with antisocial personality disorder, 39% with drug use disorder, 24% with alcohol use disorder, 18% with hepatitis C, and 11% with major depression. Healthcare provision inadequate.

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