A large Australian study suggests that atypical depression is genetically, metabolically and clinically distinct, with poorer response to SSRIs and SNRIs.
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A new meta-analysis from Toutountzidis and colleagues finds trauma-focused therapies meaningfully reduce delusions in psychosis, but offer limited benefit for hallucinations. Younger people gain most.
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Two major reviews find early intervention shows promise for youth mental health, but the evidence is stronger for psychosis than for anxiety and depression.
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New research suggests that weight gained in the first 12 weeks of antipsychotic treatment is the biggest driver of long-term obesity in psychosis.
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For the first time, people with lived experience, carers and clinicians have identified the top 10 research priorities for body clocks and mental health.
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A 28-predictor model using routine mental health records correctly identified risk for psychotic or bipolar disorders around 80% of the time, outperforming existing assessment tools in a study of 127,000 people.
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Simulation study suggests computerised adaptive testing could reduce paranoia assessment from 10 items to 4 while maintaining accuracy. Real-world implementation and clinical testing needed.
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Umbrella review of global prison populations finds 40% with antisocial personality disorder, 39% with drug use disorder, 24% with alcohol use disorder, 18% with hepatitis C, and 11% with major depression. Healthcare provision inadequate.
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Feasibility trial found resistance training was safe and acceptable for people with psychosis in psychiatric rehabilitation wards, challenging assumptions about patient capabilities and safety.
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New research reveals how antipsychotic medications affect working memory speed in healthy adults, providing crucial insights into the cognitive side effects of these widely prescribed drugs.
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