Loneliness in adolescence and suicidal thoughts: is depression the link?

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About 1 in 10 teenagers experience severe loneliness. A new 13-year study examines what this means for their future mental health and suicide risk.

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CBT for depression in primary care: gold standard, or one option among many?

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Does CBT really outperform other treatments for depression in primary care settings? A recent systematic review suggests patients may have more options than we think.

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Targeting inflammation in depression: a proof-of-concept worth following

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A single dose of tocilizumab cleared inflammation in depressed patients, but did it ease their symptoms? A proof-of-concept RCT with cautious promise.

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Brain scans, depression, and AI: small signals, big questions

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A new study uses AI on brain scans to predict depression. The findings are modest, but the implications go beyond the hospital.

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Can stronger social connections really help reduce depression?

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A new umbrella review shows in-person social engagement reduces depression, especially for older adults and people most at risk of isolation.

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How sleep changes across later life, and what it means for mental health

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A large UK Biobank study tracked sleep in over 77,000 adults. Here’s what the data reveals about age, sex and mood.

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Chronic pain in mental disorders: a widely overlooked comorbidity

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Chronic pain is highly common across mental disorders, yet routinely overlooked. This umbrella review of nearly a million people makes the case for integrated care.

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Tackling loneliness could reduce depression for sexual minority older adults

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Loneliness accounted for 15% of the higher depression risk in sexual minority older adults, a new English cohort study finds, pointing to a modifiable pathway.

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MDMA-assisted therapy for depression: a promising but early first step

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A small proof-of-principle trial suggests MDMA-assisted therapy may be feasible and effective for depression, but open-label design and a highly pre-treated sample urge caution.

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A stitch in time: early intervention for young people – promising but patchy evidence

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Two major reviews find early intervention shows promise for youth mental health, but the evidence is stronger for psychosis than for anxiety and depression.

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