Just how good are antipsychotics at preventing relapse? Bridging the efficacy-effectiveness gap

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Samei Huda summarises a new network meta-analysis in the Lancet Psychiatry on the efficacy and effectiveness of antipsychotics for schizophrenia in research settings, such as randomised controlled trials, versus real-world and clinical settings.

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Opening ward doors doesn’t make staff any more coercive

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John Baker summarises a new Norwegian trial published last week, which compares an open-door policy to treatment-as-usual in urban psychiatric inpatient wards.

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Risk factors for depression relapse while on long-term maintenance antidepressant treatment

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In her debut blog, Asha Ladwa discusses a secondary analysis of data from the ANTLER trial, which investigated the clinical factors associated with relapse in primary care patients on long-term maintenance antidepressants.

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SMS CBT TLC CYP? 🤔 Does delivering cognitive behavioural therapy via text messages help improve depression in young people?

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Becky Appleton summarises a randomised controlled trial investigating the effectiveness and acceptability of text-based Cognitive Behavioural Therapy for improving depression in young adults.

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Early intervention for psychosis: better outcomes in the short term?

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Emanuele Osimo blogs about the 20-year follow up of the OPUS trial, which tested early intervention services for people with first-episode schizophrenia spectrum disorder.

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Reducing stigma and sickness absence: can a low intensity psychological intervention help us ‘Prevail’?

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Emmeline Lagunes-Cordoba summarises a cluster randomised controlled trial exploring the effectiveness of a low-intensity psychological intervention to reduce mental health stigma and improve help-seeking in the workplace.

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Guided self-help for anxiety: the importance of choice

Only 7% of the participants accepted being randomised, while 93% chose their treatment, showing a preference for CAT-GSH; however, CAT-GSH and CBT-GSH were found to result in similar anxiety outcomes at the follow-up assessments.

In her latest blog, Francesca Zecchinato summarises findings from a recent pragmatic, partially randomised, patient preference trial on two forms of guided self-help for anxiety.

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Can hearing interventions slow down cognitive decline?

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In this blog, Daisy Long and the elf apprentices that took part in the woodland workshop undertook a group critical analysis on Lin, F.R., Pike, J.R., Albert. M.S., Arnold, M., Burgard, S., Chisolm, T. & others (2023) paper on Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multi-centre, randomized controlled trial.

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Brief interpersonal therapy may help relieve maternal depression during pregnancy

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In this blog, Francesca Kingston summaries a clinical trial from the US Care Project, which investigated whether depression can be reduced during pregnancy and before birth using a brief, safe intervention.

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The Body Project peer-led eating disorders prevention programme shows promise for bulimia nervosa and purging disorder

Across the three trials, 10.6% of Body Project participants went on to develop an eating disorder in comparison to 17.4% of the control groups, indicating promise in the intervention.

Georgie Parker summarises a recent study which outlines the results of three trials exploring the effectiveness of a peer-led dissonance-based programme for preventing the onset of eating disorders.

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