Does CBT really outperform other treatments for depression in primary care settings? A recent systematic review suggests patients may have more options than we think.
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A large Australian study suggests that atypical depression is genetically, metabolically and clinically distinct, with poorer response to SSRIs and SNRIs.
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The EPISODE trial of psychedelic-assisted therapy for ‘treatment-resistant depression’ finds only modest effects, with a few clear responders, but lingering methodological questions.
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A single dose of tocilizumab cleared inflammation in depressed patients, but did it ease their symptoms? A proof-of-concept RCT with cautious promise.
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A small proof-of-principle trial suggests MDMA-assisted therapy may be feasible and effective for depression, but open-label design and a highly pre-treated sample urge caution.
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Non-physical domestic violence (intimidation, control, property damage) in childhood showed stronger associations with adult mental health disorders than physical violence in large Australian study.
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This study used Mendelian randomisation to test potential causal relationships between depression and 137 traits. Depression liability was linked to somatic diseases, inflammation, suicide risk, insomnia, lower cognitive function and functional impairments, though findings require validation.
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A big new study suggests that certain genetic traits—like insomnia risk and neuroticism—may make depression harder to treat, while protective traits include education and cognitive ability.
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Psychiatric disorders are highly heritable, but are the genes we identify in GWAS the same ones our medications target? This new study digs into the overlap and raises questions about how we develop treatments.
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Despite strong evidence, collaborative care remains underused in the NHS. This blog explores new findings that highlight which components of the model are most effective in reducing depression symptoms.
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