New and emerging treatments for major depressive disorder

Sprouts of hope for treatment resistant depression?

Kirsten Lawson summarises a new ‘state of the art review’ in the BMJ which focuses on novel and emerging pharmacotherapy and neuromodulation for people with ‘treatment resistant depression’.

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From parent to child: understanding the risk of anxiety in families affected by mood disorders

Close up faces in row, diverse women smile looking at camera, little cute girl, her adult mother, mature grandmother and old great-grandmother portraits. Multi-generational family, heredity, offspring

Aslihan Baser summarises a systematic review and meta-analysis investigating the risk for developing anxiety disorders in children whose parents experience mood disorders.

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Can proteomics improve our prediction of depression remission?

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Jonas Hagenberg discusses new insights into the possible use of proteomics (the large-scale study of proteins) for improving our prediction of depression remission.

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Antidepressant withdrawal: recommendations for support from people with lived experience

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Hannah Bowers summarises a study exploring the need for antidepressant withdrawal support, from 708 survey respondents with lived experience.

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Capturing the lived experience of depression

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Charlotte Walker blogs about a recent World Psychiatry ‘bottom-up review’ on the lived experience of depression; co-written by experts by experience and academic researchers.

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Are transdiagnostic mental health interventions the future of treatment?

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Isabeau Tindall summarises a recent meta-analysis by Pim Cuijpers and colleagues investigating the effective of transdiagnostic treatments for depression and anxiety.

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Is anxiety a gateway to other mental health problems? Comorbidities with depression and other anxiety disorders

Results from the current study largely replicated findings from the NESDA dataset in demonstrating that those with comorbid anxiety and/or depression have more severe presentations that anxiety or depression alone.

Nina Higson-Sweeney summarises a study using data from the UK-based GLAD and COPING NBR cohorts to investigate factors associated with anxiety disorder comorbidity with anxiety and depression.

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Self-stigma for people with depression: systematic review presents global prevalence data, risk factors and protective factors

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Pattie Gonsalves blogs about the stigma that people with depression can sometimes feel towards themselves; summarising a recent systematic review that estimates the global prevalence of depression self-stigma, alongside risk factors and protective factors.

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Clinical severity and instability as predictors for psychiatric hospitalisation: can one size fit all? 

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Florian Walter summarises a retrospective cohort study published in The Lancet Psychiatry that investigates whether early trajectories of clinical global impression severity can transdiagnostically predict later psychiatric hospitalisation.

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Brief interpersonal therapy may help relieve maternal depression during pregnancy

a pregnant woman in a grey top makes a heart shape with her hands over her pregnancy bump

In this blog, Francesca Kingston summaries a clinical trial from the US Care Project, which investigated whether depression can be reduced during pregnancy and before birth using a brief, safe intervention.

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