New genes implicated in Alzheimer’s disease #LetsTalkMentalHealthII

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Byron Creese writes a #LetsTalkMentalHealthII blog about a recent genome-wide meta-analysis which identifies new loci and functional pathways influencing Alzheimer’s disease risk.

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Genetic predictors of depression trajectories in adolescence

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Megan Skelton explores a study that uses polygenic scores in the context of longitudinal developmental data, to characterise developmental trajectories and the role of neuropsychiatric genetic risk variants in early-onset depression.

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Genetics of depression: understanding risk and improving treatment

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Douglas Levinson on a genome-wide meta-analysis of depression in 807,553 individuals, which identifies 102 independent variants relating to the genetics of depression.

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Improving antidepressant outcomes: what works for whom and why?

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Thalia Eley and Gerome Breen explore a new systematic meta-review of predictors of antidepressant treatment outcome in depression, which looks at clinical and demographic variables, but also biomarkers including both genetic and neuroimaging data.

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What can genetics tell us about the link between cannabis and schizophrenia? #MHQT

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Suzi Gage summarises a recent GWAS of lifetime cannabis use, which reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Interesting new evidence ahead of our Mental Health Question Time #MHQT event in London tomorrow.

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Depression and anxiety: two sides of the same coin? #TransDX2018

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Ava Schulz reviews a paper by Mansell and McEvoy which looks at psychopathology in a heterogenous clinical sample of anxiety and depression.

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The genetics of depression (and anxiety!)

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Thalia Eley shares her thoughts on a recent Nature genome-wide association study of depression phenotypes in the UK Biobank, which uses different definitions of depression to provide more tractable targets for future genetic studies.

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Understanding the genetics of antipsychotic treatment response

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Marcus Munafo looks at a Chinese genome-wide association study that claims to have identified some of the genes associated with response to antipsychotic treatment.

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Risk factors and peripheral biomarkers for schizophrenia spectrum disorders

This 'umbrella review' aimed to systematically appraise the meta-analyses of observational studies on risk factors and peripheral biomarkers for schizophrenia spectrum disorders.

Marcus Munafo considers the findings of a systematic review of meta-analyses of observational studies, which looks at risk factors and peripheral biomarkers for psychotic disorders on the schizophrenia spectrum.

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Autoimmune and autoinflammatory diseases associated with higher risk of eating disorders

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Francesca Solmi appraises and summaries a recent population-based cohort study that explores the links between eating disorders and autoimmune and autoinflammatory diseases.

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