Ben Janaway explores a recent review in JAMA Psychiatry on the emerging clinical neuroscience of Autism Spectrum Disorder.
[read the full story...]What causes Autistic Spectrum Disorder?
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Who gets bullied? Using genetic information to identify individual vulnerabilities
Lucy Bowes explores a multi-polygenic score approach to identifying individual vulnerabilities associated with the risk of bullying, which suggests that depression, ADHD, risk taking, BMI and intelligence are independently associated with exposure to bullying.
[read the full story...]New genes implicated in Alzheimer’s disease #LetsTalkMentalHealthII
Byron Creese writes a #LetsTalkMentalHealthII blog about a recent genome-wide meta-analysis which identifies new loci and functional pathways influencing Alzheimer’s disease risk.
[read the full story...]Genetic predictors of depression trajectories in adolescence
Megan Skelton explores a study that uses polygenic scores in the context of longitudinal developmental data, to characterise developmental trajectories and the role of neuropsychiatric genetic risk variants in early-onset depression.
[read the full story...]Genetics of depression: understanding risk and improving treatment
Douglas Levinson on a genome-wide meta-analysis of depression in 807,553 individuals, which identifies 102 independent variants relating to the genetics of depression.
[read the full story...]Improving antidepressant outcomes: what works for whom and why?
Thalia Eley and Gerome Breen explore a new systematic meta-review of predictors of antidepressant treatment outcome in depression, which looks at clinical and demographic variables, but also biomarkers including both genetic and neuroimaging data.
[read the full story...]What can genetics tell us about the link between cannabis and schizophrenia? #MHQT
Suzi Gage summarises a recent GWAS of lifetime cannabis use, which reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Interesting new evidence ahead of our Mental Health Question Time #MHQT event in London tomorrow.
[read the full story...]Depression and anxiety: two sides of the same coin? #TransDX2018
Ava Schulz reviews a paper by Mansell and McEvoy which looks at psychopathology in a heterogenous clinical sample of anxiety and depression.
[read the full story...]The genetics of depression (and anxiety!)
Thalia Eley shares her thoughts on a recent Nature genome-wide association study of depression phenotypes in the UK Biobank, which uses different definitions of depression to provide more tractable targets for future genetic studies.
[read the full story...]Understanding the genetics of antipsychotic treatment response
Marcus Munafo looks at a Chinese genome-wide association study that claims to have identified some of the genes associated with response to antipsychotic treatment.
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