Maintenance or discontinuation of antidepressants for depression? Findings from the ANTLER trial

For every 6 people stopping their medication there was one additional relapse compared to those who maintained their antidepressant treatment, suggesting that stopping medication has an increased risk of relapse.

Raphael Rifkin-Zybutz and Sameer Jauhar summarise the recently published ANTLER trial, which explores whether antidepressant maintenance can reduce the risk of relapse in depression.

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The benefits and harms of antidepressants for youth depression and anxiety #ActiveIngredientsMH

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Mark Horowitz and Joanna Moncrieff consider a new #ActiveIngredientsMH review published today in The Lancet Psychiatry, which looks at the knowns and unknowns of antidepressant treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action.

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Expertise from outside the Academy: tapering off antidepressants

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Mark Horowitz considers a recent article written by Adele Framer, Founder of SurvivingAntidepressants.org, which describes how best to help people who are tapering off antidepressants.

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Antidepressant discontinuation and continuation: new Cochrane review finds miasma of confound

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Adele Framer, Founder of SurvivingAntidepressants.org, explores a recent Cochrane review on antidepressant discontinuation versus continuation for adults with depression or anxiety, which highlights huge uncertainty in the science about antidepressant withdrawal.

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Mindfulness to support antidepressant withdrawal: patient views and experiences

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Hannah Bowers writes her debut blog on a recent qualitative study, which explores how mindfulness-based cognitive therapy can help people stop taking antidepressants and recover from depression. This paper includes the views and perspectives of participants in the 2015 PREVENT trial.

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Antidepressant withdrawal: slower and lower tapering of SSRIs

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A group of UCL Masters Students summarise a recent personal view by Mark Horowitz and David Taylor about tapering of SSRI treatment to mitigate antidepressant withdrawal symptoms.

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Antidepressant withdrawal: reviewing the paper behind the headlines

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Joseph Hayes and Sameer Jauhar set the record straight on antidepressant withdrawal. They show how the recent review by Davies and Read is seriously flawed and does not accurately portray the data. They conclude that we urgently need clearer evidence on the incidence, severity and duration of any symptoms related to antidepressant withdrawal.

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Non-medical use of prescription drugs #NonMedicalDrugs

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Ian Hamilton and Julia Buxton from the University of York preview the #NonMedicalDrugs event that will take place in York on Friday 16th March 2018.

The meeting will bring together people who can offer personal and professional insights of the extent of the issue and how we can support people who develop problems.

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CBT plus taper may help reduce short-term benzodiazepine use

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John Baker summarises a recent Cochrane systematic review of psychosocial interventions for benzodiazepine harmful use, abuse or dependence.

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Promoting smoking cessation in people with schizophrenia

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Meg Fluharty summarises a recent clinical overview of smoking cessation in people with severe mental illness, which provides useful practical advice to clinicians who are trying to help service users with schizophrenia, psychosis and other conditions to quit smoking

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