Genetic predictors of depression trajectories in adolescence

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Megan Skelton explores a study that uses polygenic scores in the context of longitudinal developmental data, to characterise developmental trajectories and the role of neuropsychiatric genetic risk variants in early-onset depression.

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Genetics of depression: understanding risk and improving treatment

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Douglas Levinson on a genome-wide meta-analysis of depression in 807,553 individuals, which identifies 102 independent variants relating to the genetics of depression.

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Improving antidepressant outcomes: what works for whom and why?

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Thalia Eley and Gerome Breen explore a new systematic meta-review of predictors of antidepressant treatment outcome in depression, which looks at clinical and demographic variables, but also biomarkers including both genetic and neuroimaging data.

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