Off-label antidepressants: limited evidence to support their use

health-1628372_1280

John Baker reports on Canadian study looking at prescriptions of off-label antidepressants in primary care, which concludes that when antidepressants were used outside of their licence, there was usually not strong evidence supporting the respective indication.

[read the full story...]

Antidepressants for depression in Alzheimer’s Disease

mental-health-2211184_1280

The EQUATOR Publication School #EQPubSchool group summarise a systematic review and meta-analysis on the efficacy of antidepressants for depression in Alzheimer’s Disease, which finds no statistical difference between antidepressants and placebo.

[read the full story...]

Psychotherapies for depression in children and adolescents: all of equal IMPACT?

sad-woman

Jasmin Wertz summarises the recently published IMPACT trial, which found that CBT, short-term psychoanalytical psychotherapy and brief psychosocial interventions (psychoeducation) were all equally effective in treating depression in children and young people.

[read the full story...]

Antidepressants for bipolar depression: weighing up the benefits and harms

7347845622_508b764a51_k

Murtada Alsaif considers a recent systematic review on the safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an atypical antipsychotic in acute bipolar depression.

[read the full story...]

One size does not fit all: divergent outcomes from CBT and antidepressants for depression

4417026016_b8ae7a8cec_b

Suzanne Dash explores a recent meta-analysis of CBT and antidepressants for depression, which looked at negative and positive responses to treatment and what predicted different outcomes.

[read the full story...]

Burning mouth syndrome: insufficient evidence for effectiveness of current treatments

Depression

This update of a 2005 Cochrane review identified 23 RCTs but a limited number at low risk of bias so there is insufficient evidence to support or refute the use of any interventions in managing burning mouth syndrome.

[read the full story...]

In praise of little: sponsorship bias in depression research

2737146722_8681e3711e_o

Samei Huda welcomes a new meta-analysis of sponsorship bias in the comparative efficacy of psychotherapy and pharmacotherapy for adult depression.

[read the full story...]

Does taking antidepressants during pregnancy harm the child? Here are the facts

baby-boy-shoes-on-belly

Ian Jones summarises a number of studies that consider the benefits and harms of antidepressants during pregnancy, including a recent cohort study that found that exposure to antidepressants in the womb is associated with a modest increased risk of speech and language disorders.

[read the full story...]

Time to stop prescribing antidepressants to young people with depression?

photo-1456397807017-5a6b47d257f4

Andrew Shepherd considers the implications of a recent network meta-analysis of the efficacy and tolerability of antidepressants for children and adolescents with depression.

[read the full story...]

Specialist depression service may help people with persistent depression

photo-1461783436728-0a9217714694

Ben Hannigan reports on a recent RCT of the efficacy and cost-effectiveness of a specialist depression service versus usual specialist mental health care to manage persistent depression.

[read the full story...]