Maintenance or discontinuation of antidepressants for depression? Findings from the ANTLER trial

For every 6 people stopping their medication there was one additional relapse compared to those who maintained their antidepressant treatment, suggesting that stopping medication has an increased risk of relapse.

Raphael Rifkin-Zybutz and Sameer Jauhar summarise the recently published ANTLER trial, which explores whether antidepressant maintenance can reduce the risk of relapse in depression.

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Psychotherapy and antidepressant tapering can help people at risk of depression relapse, but more evidence needed before we can provide personalised treatment

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Jessica Scaife reviews a individual patient data meta-analysis exploring the continuation of antidepressants versus sequential psychological interventions to prevent relapse in depression.

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The benefits and harms of antidepressants for youth depression and anxiety #ActiveIngredientsMH

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Mark Horowitz and Joanna Moncrieff consider a new #ActiveIngredientsMH review published today in The Lancet Psychiatry, which looks at the knowns and unknowns of antidepressant treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action.

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Expertise from outside the Academy: tapering off antidepressants

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Mark Horowitz considers a recent article written by Adele Framer, Founder of SurvivingAntidepressants.org, which describes how best to help people who are tapering off antidepressants.

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Turn on, or tune out? Is psilocybin assisted therapy close to becoming a first-line treatment for depression?

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James Rucker and Sameer Jauhar summarise a recent RCT on the effectiveness of psilocybin assisted therapy versus escitalopram assisted therapy for major depressive disorder.

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New evidence on treatments for symptoms of depression in dementia

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Andrew Sommerlad appraises a recent review on the efficacy of interventions for depression in people with dementia, which identified several non-drug treatments that can have a meaningful effect on depressive symptoms in dementia.

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Antidepressants for youth depression: Cochrane review confirms they should not be the first port of call

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Susannah Murphy summarises a new Cochrane review and network meta-analysis, which provides the best evidence to date about new generation antidepressants for depression in children and adolescents.

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Antidepressant discontinuation and continuation: new Cochrane review finds miasma of confound

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Adele Framer, Founder of SurvivingAntidepressants.org, explores a recent Cochrane review on antidepressant discontinuation versus continuation for adults with depression or anxiety, which highlights huge uncertainty in the science about antidepressant withdrawal.

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Living in anxious times? The rise of anxiety disorders in the UK

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Alice Grishkov and Derek Tracy explore a recent paper, which finds that generalised anxiety disorder is on the rise in the UK, especially in young women.

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Majority of people with ADHD in Ireland still thought to be untreated, despite increase in treatment rates

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In her debut blog, Poppy Ellis Logan summarises a longitudinal study which finds rates of ADHD prescription increased in Ireland between 2005 and 2015.

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