Linda Gask summarises findings from a cross-sectional online survey that investigated the Smallest Worthwhile Difference necessary for individuals with depression to consider taking antidepressants.
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Chris Sampson evaluates a cost-of-illness analysis on the economic burden of Obsessive Compulsive Disorder in the UK.
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In her debut blog, Asha Ladwa discusses a secondary analysis of data from the ANTLER trial, which investigated the clinical factors associated with relapse in primary care patients on long-term maintenance antidepressants.
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Hannah Bowers summarises a study exploring the need for antidepressant withdrawal support, from 708 survey respondents with lived experience.
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Amelia Talbot summarises a qualitative meta-synthesis exploring people’s experiences of living with ‘treatment-resistant’ depression.
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The 2022 review by Moncrieff et al on the serotonin theory of depression received a great deal of media coverage. In this blog, Rebecca Wilkinson and Sameer Jauhar shed fresh light on this research and what it means for mental health science and practice.
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Angharad de Cates reviews a recent Danish trial, which finds that escitalopram reduced participants’ reinforcement sensitivity compared to those on placebo. This lower reinforcement sensitivity may be similar to the emotional blunting effect often reported by patients during SSRI treatment.
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Adele Framer summarises a systematic review which finds that major guidelines on antidepressant discontinuation only give clinicians vague guidance on distinguishing withdrawal from relapse.
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This review of all treatments for the relief of pain associated with burning mouth syndrome (BMS) as compared with no intervention or placebo included 44 RCTs. There was moderate certainty evidence that clonazepam is likely to reduce the pain of BMS compared with placebo.
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In his debut blog, Nick Meader tackles a huge umbrella review of youth mental health interventions, which presents the efficacy and acceptability of 72 different approaches to help children and young people.
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