Can proteomics improve our prediction of depression remission?

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Jonas Hagenberg discusses new insights into the possible use of proteomics (the large-scale study of proteins) for improving our prediction of depression remission.

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Sitting in the waiting room: what happens when anxiety disorders are left untreated?

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In her debut blog, Beth Hindhaugh summarises a systematic review and meta-analysis of 173 studies examining the untreated course of anxiety disorders, which finds that for some people, anxiety disorders can improve without treatment.

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The global burden of disease from mental disorders remains high

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Alejandro Arguelles Bullon summarises the latest Global Burden of Disease study (2019) looking at the prevalence, incidence and impact that mental disorders have on our lives, which shows no reduction in the burden over the last 30 years.

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ADHD remission: why do some children ‘outgrow’ ADHD whilst others don’t?

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A group of UCL Mental Health Masters students summarise a recent literature review that explores the potential pathways to ADHD remission.

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Anorexia nervosa: relapse, remission and recovery

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Sarah McDonald asks: What happens after treatment? She summarises a recent systematic review of relapse, remission, and recovery in anorexia nervosa.

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Outcomes in first episode manic psychosis

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Matthew Broome writes his debut Mental Elf blog on a three-year clinical and functional outcome comparison between first episode manic psychosis and first-episode schizophrenia.

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CBT versus psychodynamic psychotherapy for social anxiety disorder: long live the dodo or time for a change in research emphasis?

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Andrew Shepherd appraises a study of the long-term outcomes of psychodynamic therapy and cognitive-behavioral therapy in social anxiety disorder, which finds both therapies are efficacious in treating social anxiety disorder in the short- and long-term.

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And if we do nothing? A new systematic review explores natural PTSD remission rates

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Who naturally recovers from PTSD and why? A recent meta-regression analysis finds an overall natural remission rate for PTSD of 44%, with no increase in remission after longer observation periods.

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Cochrane review finds ‘solid’ evidence for CBT for anxiety in young people, but lacks evidence for long-term benefits

Anxiety disorders, such as generalised anxiety disorder (GAD), social anxiety, panic disorder and phobias, are common and affect between 5 – 19% of all children and adolescents (Costello, 2004; as cited in James et al, 2013, pg. 6).  Anxiety problems in childhood or adolescence can disrupt social and educational life, and may persist into adulthood. [read the full story…]

Escitalopram provides cost-effective remission from depression, according to new meta-analysis

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I really enjoyed the discussion in the Guardian over the weekend about poor quality trials and pharmaceutical industry techniques that overhype their drugs in an attempt to shift units. Ben Goldacre’s new Bad Pharma book is well worth a read. New reviews about antidepressants come thick and fast and it’s often hard to know what [read the full story…]