The EPISODE trial of psychedelic-assisted therapy for ‘treatment-resistant depression’ finds only modest effects, with a few clear responders, but lingering methodological questions.
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A small proof-of-principle trial suggests MDMA-assisted therapy may be feasible and effective for depression, but open-label design and a highly pre-treated sample urge caution.
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This network meta-analysis of 76 trials found that slow tapering (over 4 weeks) combined with psychological support was most effective for preventing relapse when stopping antidepressants. Abrupt discontinuation and fast tapering substantially increased relapse risk and should be avoided.
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How often do people with eating disorders switch diagnoses, recover, or relapse? This large Danish study follows more than 10,000 people over nearly a decade, uncovering patterns of remission and genetic vulnerability that could help shape more personalised care.
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Is teenage depression more likely to come back later in life? A new population study challenges assumptions and finds similar recurrence risks in both adolescents and adults.
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Jonas Hagenberg discusses new insights into the possible use of proteomics (the large-scale study of proteins) for improving our prediction of depression remission.
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In her debut blog, Beth Hindhaugh summarises a systematic review and meta-analysis of 173 studies examining the untreated course of anxiety disorders, which finds that for some people, anxiety disorders can improve without treatment.
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Alejandro Arguelles Bullon summarises the latest Global Burden of Disease study (2019) looking at the prevalence, incidence and impact that mental disorders have on our lives, which shows no reduction in the burden over the last 30 years.
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A group of UCL Mental Health Masters students summarise a recent literature review that explores the potential pathways to ADHD remission.
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Sarah McDonald asks: What happens after treatment? She summarises a recent systematic review of relapse, remission, and recovery in anorexia nervosa.
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