Opioid Agonist Treatment associated with 50% lower risk of mortality, but political epiphany still needed to reduce drug-related deaths

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Ian Hamilton appraises a systematic review and meta-analysis on the association of opioid agonist treatment with all-cause mortality and specific causes of death among people with opioid dependence.

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Death from COVID-19: should we be prioritising people with schizophrenia for vaccination?

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In her debut blog, Aneta Zarska reviews a cohort study which looks at the links between death from COVID-19 and a range of mental health conditions, including schizophrenia, depression and anxiety.

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SlowMo: an app to improve thinking biases in people experiencing paranoia

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Imogen Bell blogs about a recent randomised controlled trial of the SlowMo app, which aimed to slow down thinking patterns and correct interpretation biases in people experiencing paranoia.

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Psychotherapy for depression across different age groups

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David Hallford summarises a recent systematic review and meta-analysis on the effectiveness of psychotherapy for depression across the lifespan.

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CBT delivery formats for adult depression: group, telephone & guided self-help all as effective as individual therapy?

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Kinga Antal reviews a network meta-analysis which finds that individual, group, telephone and guided self-help CBT are all equally effective for treating depression in adults.

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CBT for health anxiety: should it be delivered in person or online?

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Francesca Bentivegna explores a timely RCT concluding that delivering internet-based (email) CBT for health anxiety is non-inferior to face to face CBT in the short-term. The study also concludes that iCBT is more cost-effective.

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In harm’s way: psychiatric diagnosis and risks of being subjected to and perpetrating violence

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Sarah Steeg discusses a cohort study finding that people with a psychiatric diagnosis are 3-4 times more likely to be a victim or perpetrator of violence.

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Are antidepressants safe? A new umbrella review of observational studies suggests they are, but we need more accurate data

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Andrea Cipriani and Anneka Tomlinson scrutinise a brand new umbrella review of the associations between antidepressants and adverse health outcomes, which suggests that antidepressants are safe for most people who experience mental health difficulties.

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What causes Autistic Spectrum Disorder?

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Ben Janaway explores a recent review in JAMA Psychiatry on the emerging clinical neuroscience of Autism Spectrum Disorder.

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Intranasal esketamine for treatment-resistant depression: the first clinical study

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Jodi Rintelman writes her debut elf blog on the first randomised controlled trial on the efficacy and safety of intranasal esketamine as an adjunctive treatment to antidepressants for treatment-resistant depression.

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