Can interventions help to improve social functioning in youth at risk of psychosis?


Carla McEnery summarises a systematic review and meta-analysis of interventions and social functioning in youth at risk of psychosis.

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Alternatives to medication for children and young people with ADHD


Joff Jones summarises a recent systematic review, which looks at the evidence for a wide range of non-pharmacological treatments for ADHD. The review finds the strongest evidence for diet, child/parent training and behavioural interventions.

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Preventing psychosis: no one intervention is better than the rest


A group of UCL Mental Health Masters students summarise a recent network meta-analysis that highlights a lack of evidence about specific interventions for preventing psychosis.

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Omega-3 fatty acids to prevent psychosis: the importance of replication (NEURAPRO trial)


Raphael Underwood summarises the NEURAPRO trial, which concludes that Omega-3 fatty acids are no better than placebo at preventing transition to psychosis in young people at ultrahigh risk for psychotic disorders.

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Omega-3 fatty acids for depression: Cochrane find insufficient evidence to support use


Lisa Burscheidt summarises a recent Cochrane systematic review of Omega-3 fatty acids for depression in adults, which finds a lack of evidence to determine the effects of n-3PUFAs as a treatment for major depressive disorder.

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Lifestyle changes for cognition and dementia: better than a new drug?


Should all molecular research institutes looking at neurodegenerative diseases be replaced by parks, playgrounds and cycle paths? Mark Horowitz highlights a recent systematic review of modifiable risk factors associated with cognition and dementia, which suggests that from a public health perspective, there may be some sense in this idea.

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New guideline says lithium still appears to have the most robust evidence base as a long-term treatment for bipolar disorder


Bipolar disorder features as one of the top ten disabling disorders for working age adults. There are numerous risks including suicide, increased mortality and reduced social functioning associated with the disorder. Key to enabling recovery is preventing acute episodes from occurring, with each episode increasing the risk of future ones. Therefore ensuring long-term maintenance treatment [read the full story…]

More research needed before polyunsaturated fatty acids can be recommended for ADHD in children and adolescents


Drug treatments are commonly used to treat children and young people with attention deficit hyperactivity disorder (ADHD). Methylphenidate and amphetamine are two of the most popular, but these are not effective for all patients and sometimes cause problematic side effects. Children and adolescents with ADHD have been shown to have significantly lower plasma and blood [read the full story…]

Omega-3 fish oil supplements don’t help with cognitive decline or dementia in the short-term, according to new Cochrane review


Fish oil supplements are big business. The worldwide omega-3 market has recently been valued at around $5 billion with 40% growth predicted between 2010 and 2015. Omega-3 fatty acids are fats responsible for many important jobs in the body. We get these fats through our daily diets and the three major omega-3 fats are: Alpha [read the full story…]

Systematic review finds limited evidence for the use of omega-3 fatty acids in autism spectrum disorders


Previous research has highlighted that people with autism spectrum disorders may be deficit in omega-3 fatty acids and that taking supplements may help to improve the symptoms of the condition. This new Cochrane systematic review set out to review the efficacy of omega-3 fatty acids for improving core features of autism spectrum disorder (e.g. social [read the full story…]