Gut microbiome disruptions in depression: shifting the focus to metabolic signatures in blood

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Gerard Clarke explores a recent study which looks into the interplay of metabolome and gut microbiome in individuals with major depressive disorder.

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Does what you eat affect how you feel?

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Daisy Crick summarises a recent paper on the casual relationship between polyunsaturated fatty acids and depression.

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Omega-3 fatty acids as an adjunct to non-surgical periodontal therapy

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This review assessing the adjunctive effect of omega-3 (ω-3) fatty acids and non-surgical periodontal therapy (SRP)on probing pocket depth (PPD) and the clinical attachment level (CAL) included 10 RCTs. The findings suggest that adjunctive ω-3 fatty acids provides a 0.39 mm improvement in PPD and 0.41 mm of CAL gain.

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No evidence that medication can prevent PTSD in people exposed to trauma, according to new Cochrane review

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In his debut blog, Richard Meiser-Stedman explores a recent Cochrane systematic review which finds no evidence for the use of medication to prevent the onset of PTSD in people who have been exposed to a traumatic event.

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Dietary omega-3 fatty acids as an adjunct to non-surgical periodontal treatment

Fatty acid supplementation may have involved omega - 3 or -6 oils or both.

This review assessing the impact of dietary omega-3 fatty acids as an adjunct to non-surgical periodontal treatment when compared with periodontal treatment alone included 10 trials ivolving a total of 467 patients. The studies found statistically significant improvements in clinical attachment level (CAL) and periodontal probing depth (PPD) but the studies are generally small and short-term.

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Omega-3 supplements for depression and anxiety #ActiveIngredientsMH

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Ashlee Negrone summarises a systematic review and meta-analysis on omega-3 supplements for depression and anxiety in adults, and briefly introduces their Active Ingredients project on omega-3 for youth depression and anxiety.

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Can interventions help to improve social functioning in youth at risk of psychosis?

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Carla McEnery summarises a systematic review and meta-analysis of interventions and social functioning in youth at risk of psychosis.

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Alternatives to medication for children and young people with ADHD

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Joff Jones summarises a recent systematic review, which looks at the evidence for a wide range of non-pharmacological treatments for ADHD. The review finds the strongest evidence for diet, child/parent training and behavioural interventions.

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Preventing psychosis: no one intervention is better than the rest

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A group of UCL Mental Health Masters students summarise a recent network meta-analysis that highlights a lack of evidence about specific interventions for preventing psychosis.

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Omega-3 fatty acids to prevent psychosis: the importance of replication (NEURAPRO trial)

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Raphael Underwood summarises the NEURAPRO trial, which concludes that Omega-3 fatty acids are no better than placebo at preventing transition to psychosis in young people at ultrahigh risk for psychotic disorders.

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