No evidence that medication can prevent PTSD in people exposed to trauma, according to new Cochrane review

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In his debut blog, Richard Meiser-Stedman explores a recent Cochrane systematic review which finds no evidence for the use of medication to prevent the onset of PTSD in people who have been exposed to a traumatic event.

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Dietary omega-3 fatty acids as an adjunct to non-surgical periodontal treatment

Fatty acid supplementation may have involved omega - 3 or -6 oils or both.

This review assessing the impact of dietary omega-3 fatty acids as an adjunct to non-surgical periodontal treatment when compared with periodontal treatment alone included 10 trials ivolving a total of 467 patients. The studies found statistically significant improvements in clinical attachment level (CAL) and periodontal probing depth (PPD) but the studies are generally small and short-term.

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Omega-3 supplements for depression and anxiety #ActiveIngredientsMH

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Ashlee Negrone summarises a systematic review and meta-analysis on omega-3 supplements for depression and anxiety in adults, and briefly introduces their Active Ingredients project on omega-3 for youth depression and anxiety.

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Can interventions help to improve social functioning in youth at risk of psychosis?

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Carla McEnery summarises a systematic review and meta-analysis of interventions and social functioning in youth at risk of psychosis.

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Alternatives to medication for children and young people with ADHD

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Joff Jones summarises a recent systematic review, which looks at the evidence for a wide range of non-pharmacological treatments for ADHD. The review finds the strongest evidence for diet, child/parent training and behavioural interventions.

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Preventing psychosis: no one intervention is better than the rest

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A group of UCL Mental Health Masters students summarise a recent network meta-analysis that highlights a lack of evidence about specific interventions for preventing psychosis.

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Omega-3 fatty acids to prevent psychosis: the importance of replication (NEURAPRO trial)

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Raphael Underwood summarises the NEURAPRO trial, which concludes that Omega-3 fatty acids are no better than placebo at preventing transition to psychosis in young people at ultrahigh risk for psychotic disorders.

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Omega-3 fatty acids for depression: Cochrane find insufficient evidence to support use

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Lisa Burscheidt summarises a recent Cochrane systematic review of Omega-3 fatty acids for depression in adults, which finds a lack of evidence to determine the effects of n-3PUFAs as a treatment for major depressive disorder.

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Lifestyle changes for cognition and dementia: better than a new drug?

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Should all molecular research institutes looking at neurodegenerative diseases be replaced by parks, playgrounds and cycle paths? Mark Horowitz highlights a recent systematic review of modifiable risk factors associated with cognition and dementia, which suggests that from a public health perspective, there may be some sense in this idea.

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New guideline says lithium still appears to have the most robust evidence base as a long-term treatment for bipolar disorder

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Bipolar disorder features as one of the top ten disabling disorders for working age adults. There are numerous risks including suicide, increased mortality and reduced social functioning associated with the disorder. Key to enabling recovery is preventing acute episodes from occurring, with each episode increasing the risk of future ones. Therefore ensuring long-term maintenance treatment [read the full story…]