Risk factors for depression relapse while on long-term maintenance antidepressant treatment

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In her debut blog, Asha Ladwa discusses a secondary analysis of data from the ANTLER trial, which investigated the clinical factors associated with relapse in primary care patients on long-term maintenance antidepressants.

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The experience of treatment-resistant depression: we need to rethink treatment for people who do not respond to antidepressants

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Amelia Talbot summarises a qualitative meta-synthesis exploring people’s experiences of living with ‘treatment-resistant’ depression.

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Is anxiety a gateway to other mental health problems? Comorbidities with depression and other anxiety disorders

Results from the current study largely replicated findings from the NESDA dataset in demonstrating that those with comorbid anxiety and/or depression have more severe presentations that anxiety or depression alone.

Nina Higson-Sweeney summarises a study using data from the UK-based GLAD and COPING NBR cohorts to investigate factors associated with anxiety disorder comorbidity with anxiety and depression.

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Solid/multicystic ameloblastoma – radical and conservative surgical approaches

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This review evaluating the efficacy of various radical and conservative surgical approaches in reducing recurrence rate for the treatment of solid/multicystic ameloblastoma included 7 retrospective cohort studies.The findings suggest that segmental resection was the best approach but the certainty of the evidence is low.

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Elective neck dissection versus observation for T1-2 oral squamous cell carcinoma

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Manas Dave looks at a review of elective neck dissection (END) versus observation for the management of T1-2 oral squamous cell carcinoma. The review included 41 studies only 5 were RCTs the remainder being retrospective studies.

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Elective neck dissection for early stage oral cancer?

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This UK multi-centre RCT of elective neck dissection(END) for early stage oral cancer found higher rates for overall and disease free survival in those patients having END.

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Oral Cancer: Elective neck dissection or watch and wait?

Bariatric surgery and marked weight loss is likely to improve knee complaints but there is a need for high quality studies

There is an ongoing debate about the management of patients with oral cavity squamous cell carcinoma and clinically negative cervical lymph nodes. Some clinicians favour preventive elective neck dissection (END) which although is linked with favourable survival has an adverse effect on quality of life while others adopt a wait and watch policy. The aim [read the full story…]

Ameloblastoma: Radical or conservative surgery?

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20 retrospective studies were included in this review of surgical approaches for ameloblastoma . The finding suggest fewer recurrences with radical approaches.

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Mouth and throat cancer: evidence for best surgical approaches uncertain

Bariatric surgery and marked weight loss is likely to improve knee complaints but there is a need for high quality studies

12 RCTs were included in this Cochrane review update of surgical approches for the management of oral and pharyngeal cancer. The certaintly of the evidence was very low as there were limited numbers of studies for each comparison.

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