A big new study suggests that certain genetic traits—like insomnia risk and neuroticism—may make depression harder to treat, while protective traits include education and cognitive ability.
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Why do people who were maltreated as children face higher risks of both mental and physical illness? A new Mendelian randomisation study suggests that metabolic markers — like triglycerides and blood sugar — may be part of the chain connecting adversity to later multimorbidity.
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A massive new multi-ancestry genetic study of bipolar disorder has uncovered hundreds of risk loci and highlighted biological pathways that may guide more precise treatments and prevention strategies in the future.
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Tim van der Es discusses a recent paper that investigates whether ADHD causally increases the risk of subsequent major depression diagnoses. The study findings underscore the need for effective treatment and assessment of ADHD and a requirement for a deeper understanding of the potential causal mechanisms linking ADHD and depression.
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Lorna Staines discusses a recent Swedish cross-sectional study of 16,255 adolescent twins, which looks at the mental health risks of using psychedelics in the real world.
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Nick Donnelly discusses how one’s genetic predisposition to shorter sleep is associated with the onset of depression in older adults.
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Nina Higson-Sweeney summarises a study using data from the UK-based GLAD and COPING NBR cohorts to investigate factors associated with anxiety disorder comorbidity with anxiety and depression.
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A group of UCL masters students consider a JAMA Psychiatry study which looks at the associations between genetic risk for adult suicide attempt and suicidal behaviours in young children in the United States.
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