Is atypical depression a clinically and genetically distinct subtype?

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A large Australian study suggests that atypical depression is genetically, metabolically and clinically distinct, with poorer response to SSRIs and SNRIs.

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Texting anxiety away: does text message CBT work for young adults?

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A new RCT tested text message CBT for generalised anxiety in young adults, with promising results. But is it ready for clinical practice?

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Coercive control and intimidation: stronger links to adult mental health than physical violence

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Non-physical domestic violence (intimidation, control, property damage) in childhood showed stronger associations with adult mental health disorders than physical violence in large Australian study.

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Predicting psychiatric hospitalisation using routinely-collected measures

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Psychiatric hospitalisation can save lives, but it also carries major personal and economic costs. Could early warning scores help predict who’s most at risk, allowing for earlier, more targeted support? This new BMJ Mental Health study by Taquet and colleagues explores the potential.

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Is intolerance of uncertainty in preschool children a risk factor for later anxiety?

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Do preschoolers who struggle with tolerating uncertainty get more anxious as they grow older? This longitudinal study followed preschool children across three timepoints, and found that the two are strongly related, but the rest of the picture is not as clear cut.

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Targeting teenage worry: network analysis of anxiety symptoms over time

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Nervousness, irritability, excessive worry, uncontrollable worry… not all anxiety symptoms weigh the same at different ages. This new Chineses study shows how anxiety networks tighten as young people grow older, and where the best intervention targets may lie.

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Pragmatic prescribing: why GPs offer beta-blockers for anxiety, despite guideline gaps

GPs’ perceived benefits of beta-blockers for anxiety underscore a need for further research and updated clinical guidance to align practice with evidence.

Beta-blockers like propranolol are being prescribed more often for anxiety in UK primary care, even though they don’t appear in national guidelines. This new qualitative study explores why GPs turn to them, and what that says about evidence, safety, and patient choice.

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One therapy, many disorders: the strengths and limitations of CBT across mental health conditions

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CBT is a cornerstone of mental health care, but how well does it really work across different disorders? This massive new meta-analysis offers some answers and raises new questions.

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Immersive virtual reality for the treatment of mental health disorders: anxiety leads the way

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Rena Gatzounis blogs about a systematic review and meta-analysis investigating the effectiveness of immersive virtual reality treatments for mental health disorders.

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Just how good are different psychotherapies for common mental health problems?

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Lisa Lloyd and Milagros Pallavicini review a recent study on psychotherapies for 8 mental disorders, finding that while most outperform control treatments, response rates remain modest.

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