A large Australian study suggests that atypical depression is genetically, metabolically and clinically distinct, with poorer response to SSRIs and SNRIs.
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New research suggests that weight gained in the first 12 weeks of antipsychotic treatment is the biggest driver of long-term obesity in psychosis.
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Once symptoms stabilise after a first episode of psychosis, should medication continue? A four-year RCT explores the risks and rewards of dose reduction.
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A 28-predictor model using routine mental health records correctly identified risk for psychotic or bipolar disorders around 80% of the time, outperforming existing assessment tools in a study of 127,000 people.
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Psychiatric disorders share genetic variants that cluster into five main factors. Understanding shared biology could improve treatment, but more diverse genetic data urgently needed.
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Feasibility trial found resistance training was safe and acceptable for people with psychosis in psychiatric rehabilitation wards, challenging assumptions about patient capabilities and safety.
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New research reveals how antipsychotic medications affect working memory speed in healthy adults, providing crucial insights into the cognitive side effects of these widely prescribed drugs.
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Only 35% of people with severe mental illness received all six cardiovascular risk factor checks within one month in this UK primary care study. Financial incentives temporarily increased comprehensive screening but effects were uneven and short-lived. Young men of non-White ethnicity were most likely to miss screening, highlighting persistent inequalities.
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A systematic review and Delphi study creates a new consensus statement on the meaning and measurement of relapse in schizophrenia, but until voices of lived experience are more fully engaged, there remains some way to go in reaching a valid consensus.
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This Danish study of over 3 million people found that having a first-degree relative with depression increased risk 2.35-times, resulting in 15% lifetime risk (compared to 7.8% in the general population). However, 60% of depression cases occurred in people with no affected close relatives, highlighting that family history is only part of the story.
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