Recent research suggests that lower IQ and cognitive performance link to higher alcohol use disorder risk, but education and societal factors can amplify or reduce this vulnerability, not genetics alone.
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This study used Mendelian randomisation to test potential causal relationships between depression and 137 traits. Depression liability was linked to somatic diseases, inflammation, suicide risk, insomnia, lower cognitive function and functional impairments, though findings require validation.
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PsyRiskMR is a new database that helps researchers investigate risk factors for common psychiatric disorders using Mendelian randomization.
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Tim van der Es discusses a recent paper that investigates whether ADHD causally increases the risk of subsequent major depression diagnoses. The study findings underscore the need for effective treatment and assessment of ADHD and a requirement for a deeper understanding of the potential causal mechanisms linking ADHD and depression.
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Gerard Clarke explores a recent study which looks into the interplay of metabolome and gut microbiome in individuals with major depressive disorder.
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Daisy Crick summarises a recent paper on the casual relationship between polyunsaturated fatty acids and depression.
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Byron Creese writes a #LetsTalkMentalHealthII blog about a recent genome-wide meta-analysis which identifies new loci and functional pathways influencing Alzheimer’s disease risk.
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Benjamin Janaway explores a recent mendelian randomisation study that looks at the causal effects between subjective wellbeing and cardiometabolic health.
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Marcus Munafo considers the findings of a systematic review of meta-analyses of observational studies, which looks at risk factors and peripheral biomarkers for psychotic disorders on the schizophrenia spectrum.
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Marcus Munafo comments on a review of the work of the Psychiatric Genomics Consortium, which in recent years has delivered an increasing flow of new knowledge about the fundamental basis of common psychiatric disorders.
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