A large Australian study suggests that atypical depression is genetically, metabolically and clinically distinct, with poorer response to SSRIs and SNRIs.
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A single dose of tocilizumab cleared inflammation in depressed patients, but did it ease their symptoms? A proof-of-concept RCT with cautious promise.
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Can training your brain’s reward circuits strengthen your immune response to vaccination? A new randomised controlled trial offers some fascinating early clues.
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Oxytocin alone didn’t speed wound healing in couples, but combined with affectionate touch and partner appreciation, it showed modest benefits. Social context matters more than hormones.
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In this small RCT, vitamin C supplementation improved attention and work absorption in healthy young adults with low vitamin C levels, alongside changes in gut bacteria and inflammation markers.
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Decades of disappointing anti-inflammatory trials for depression may have failed because they weren’t targeting the right patients. New meta-analysis shows promising results when they do.
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Although a flu vaccine activated the immune system and raised cytokine levels in this randomised trial, participants didn’t feel substantially different from the placebo group. Vaccine models can help study subtle inflammation effects.
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What if perinatal mental health started in the gut? New research from Finland suggests certain bacteria may be associated with depressive and anxiety symptoms during pregnancy and after birth, raising questions about inflammation, causality, and the future of microbiome-based screening and treatment.
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Not all childhood trauma has the same biological impact. A new study finds that adversity in late childhood is most strongly linked to immune dysregulation at age 24.
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Why do people who were maltreated as children face higher risks of both mental and physical illness? A new Mendelian randomisation study suggests that metabolic markers — like triglycerides and blood sugar — may be part of the chain connecting adversity to later multimorbidity.
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