Is depression a cause or consequence? Using genetics to untangle causal relationships

feat

This study used Mendelian randomisation to test potential causal relationships between depression and 137 traits. Depression liability was linked to somatic diseases, inflammation, suicide risk, insomnia, lower cognitive function and functional impairments, though findings require validation.

[read the full story...]

Feeding the mind: early signs that keto could help with bipolar disorder

Emerging research into the effects of a ketogenic diet have reported neuroprotective and anti-inflammatory mechanisms along with a positive metabolic effect

This pilot study explored how a ketogenic diet affects mood, metabolic health, and brain chemistry in people with bipolar disorder. The results are early, but they offer food for thought.

[read the full story...]

GLP-1 receptor agonists and the brain: could these medications boost more than metabolism?

Variety,Of,Medicines,And,Drugs.medicine,And,Healthcare,Concept.variety,Of,Medicines

GLP1 drugs are already used to treat diabetes and support weight loss, but do they have any impact on mental health? This new meta-analysis looks at the evidence from 80 clinical trials.

[read the full story...]

Gut microbiome disruptions in depression: shifting the focus to metabolic signatures in blood

nadine-primeau--ftWfohtjNw-unsplash

Gerard Clarke explores a recent study which looks into the interplay of metabolome and gut microbiome in individuals with major depressive disorder.

[read the full story...]

Risperidone and aripiprazole: genotype, metabolism and dosage

CYP2D6 genotyping before starting treatment might be valuable in clinical practice for individualising risperidone and aripiprazole treatment.

Dolly Sud writes her debut elf blog on a recent retrospective analysis, which compares dose changes of risperidone and aripiprazole with patients’ individual genotype.

[read the full story...]