Higher doses of antidepressants “not optimal”, according to new review

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Jonathon Tomlinson considers his options as a GP supporting people with depression and complex needs, after reading a new systematic review and dose-response meta-analysis, which suggests that higher doses of antidepressants bring maximum side effects with only marginal gains.

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Antidepressants and weight gain: long-term population impact #SUSANAsurvey

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Andrea Cipriani and Anneka Tomlinson summarise a 10-year cohort study of antidepressant use and incidence of weight gain.

They also launch their new SUSANA project: Survey for Understanding Side effects of ANtidepressants in Adults. Please take the SUSANA survey now!

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Antidepressant withdrawal: slower and lower tapering of SSRIs

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A group of UCL Masters Students summarise a recent personal view by Mark Horowitz and David Taylor about tapering of SSRI treatment to mitigate antidepressant withdrawal symptoms.

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Pregnancy and bipolar disorder: international prescribing consensus?

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Dean Connolly looks at an international study which asks: Is there consensus across evidence-based guidelines for the psychotropic drug management of bipolar disorder during the perinatal period?

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Dropping out of virtual reality exposure therapy for anxiety: comparison with in-vivo exposure therapy

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Aislinn Bergin writes her debut elf blog on a recent meta-analytic examination of attrition in virtual reality exposure therapy for anxiety disorders.

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Mandibular advancement devices in obstructive sleep apnoea: side effects

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21 studies mainly retrospective studies were included in this review of the dental and skeletal effects of mandibular advancement devices in treatment of obstructive sleep apnoea. while the findings suggest a number of potential side effects the quality of the available evidence in low.

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Antidepressant withdrawal: reviewing the paper behind the headlines

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Joseph Hayes and Sameer Jauhar set the record straight on antidepressant withdrawal. They show how the recent review by Davies and Read is seriously flawed and does not accurately portray the data. They conclude that we urgently need clearer evidence on the incidence, severity and duration of any symptoms related to antidepressant withdrawal.

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Adverse effects of psychotherapy for depression: new meta-analysis looks at deterioration rates

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Edel Mc Glanaghy reacquaints us with the negative effects of psychotherapies for adult depression, through an impressive new meta-analysis of trials that measure deterioration rates in patients receiving psychotherapy compared with controls.

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Low dose Amisulpride for very late onset schizophrenia-like psychosis: the ATLAS study

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Elwira Lubos summarises the recent ATLAS RCT of antipsychotic treatment for very late-onset schizophrenia-like psychosis, which provides evidence for the effectiveness of a very low dose of Amisulpride (100 mg).

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Sexual function matters to people living with serious mental illness

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Rudiger Pittrof and Elana Covshoff from SHRINE (Sexual and Reproductive Health Rights, Inclusion and Empowerment) explore a recent review, which looks at the impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management.

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