Ketamine and suicidal ideation: French trial finds modest short-term effects

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Anya Borissova reviews a French trial that claims to be evidence that “ketamine is rapid, safe in the short term, and has persistent benefits for acute care in suicidal patients”.

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How could MDMA-assisted and psilocybin-assisted psychotherapy help people with depression and PTSD?

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Anya Borissova and Philip Brooks consider a recent review exploring MDMA-assisted psychotherapy and psilocybin-assisted psychotherapy for trauma-related mental health difficulties.

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Ketamine “shows promise” as an anti-suicidal ideation agent, but will this promise ever be realised?

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Rosalind McAlpine and Karel Kieslich summarise a recent systematic review which focuses on the rapid anti-suicidal ideation effect of ketamine.

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Can ketamine metabolites and gamma power help predict clinical response for ‘treatment resistant depression’?

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Anya Borissova summarises a recent randomised placebo-controlled trial that evaluated ketamine metabolites, clinical response, and gamma power for major depression.

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Turn on, or tune out? Is psilocybin assisted therapy close to becoming a first-line treatment for depression?

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James Rucker and Sameer Jauhar summarise a recent RCT on the effectiveness of psilocybin assisted therapy versus escitalopram assisted therapy for major depressive disorder.

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Patients’ experience of ketamine treatment for depression: the ‘Ketamine and me’ project

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In her debut blog, Harmony Jiang reviews a recent qualitative study exploring patients’ experience and response to ketamine treatment for depression.

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MDMA-assisted psychotherapy for alcohol use disorder: is it feasible?

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Anya Borissova reviews a recent UK pilot study which suggests that MDMA-assisted psychotherapy is a feasible intervention to use in people with alcohol use disorder. Now we need randomised trials that can reliably measure safety and effectiveness.

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Can psilocybin-assisted psychotherapy relieve existential crises in cancer patients?

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Pascal Immanuel Michael reviews a randomised controlled trial examining long-term outcomes of psilocybin-assisted psychotherapy for existential distress in patients with cancer.

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Psilocybin for treatment-resistant depression: what are the effects on brain activity?

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Anya Borissova summarises the therapeutic mechanisms of psilocybin in treatment-resistant depression and changes noticed in the amygdala and prefrontal cortex during emotional processing.

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MDMA-assisted psychotherapy for PTSD: moving towards post-traumatic growth?

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Aster Daniel summarises a recent study exploring post-traumatic growth after MDMA-assisted psychotherapy for PTSD (post-traumatic stress disorder).

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