Can ketamine metabolites and gamma power help predict clinical response for ‘treatment resistant depression’?

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Anya Borissova summarises a recent randomised placebo-controlled trial that evaluated ketamine metabolites, clinical response, and gamma power for major depression.

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Turn on, or tune out? Is psilocybin assisted therapy close to becoming a first-line treatment for depression?

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James Rucker and Sameer Jauhar summarise a recent RCT on the effectiveness of psilocybin assisted therapy versus escitalopram assisted therapy for major depressive disorder.

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Patients’ experience of ketamine treatment for depression: the ‘Ketamine and me’ project

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In her debut blog, Harmony Jiang reviews a recent qualitative study exploring patients’ experience and response to ketamine treatment for depression.

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MDMA-assisted psychotherapy for alcohol use disorder: is it feasible?

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Anya Borissova reviews a recent UK pilot study which suggests that MDMA-assisted psychotherapy is a feasible intervention to use in people with alcohol use disorder. Now we need randomised trials that can reliably measure safety and effectiveness.

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Can psilocybin-assisted psychotherapy relieve existential crises in cancer patients?

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Pascal Immanuel Michael reviews a randomised controlled trial examining long-term outcomes of psilocybin-assisted psychotherapy for existential distress in patients with cancer.

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Psilocybin for treatment-resistant depression: what are the effects on brain activity?

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Anya Borissova summarises the therapeutic mechanisms of psilocybin in treatment-resistant depression and changes noticed in the amygdala and prefrontal cortex during emotional processing.

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MDMA-assisted psychotherapy for PTSD: moving towards post-traumatic growth?

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Aster Daniel summarises a recent study exploring post-traumatic growth after MDMA-assisted psychotherapy for PTSD (post-traumatic stress disorder).

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Ayahuasca-induced increases in brain-derived neurotrophic factor (BNDF) associated with reduced depression

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Pascal Immanuel Michael summarises a recent RCT, which looks at how a single dose of the psychedelic Ayahuasca may help people with severe depression who have not benefited from more traditional treatment.

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LSD: can psychedelics treat mental illness?

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Anya Borissova summarises a recent systematic review which brings together all of the randomised controlled trials of LSD as a treatment for mental illnesses, including alcohol and heroin dependency, depression and anxiety.

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How can psychedelics treat mental illness? #PsilocybinMedicine

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Catherine Bird writes her debut elf blog on a recent opinion review by Robin Carhart-Harris entitled: How do psychedelics work?

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