The EPISODE trial of psychedelic-assisted therapy for ‘treatment-resistant depression’ finds only modest effects, with a few clear responders, but lingering methodological questions.
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Psychedelic therapy looks impressive in trials, but when you account for the placebo effect, how does it really compare to antidepressants?
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Despite psychedelics’ roots in Indigenous and minoritised communities, clinical trials overwhelmingly centre White participants. This review highlights the consequences and asks how research can change.
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Experts from across clinical trials, psychotherapy and regulation have been reflecting on the big challenges facing the field of psychedelics and mental health, following a late 2024 webinar hosted by IAMHRF. This new commentary explores where psychedelic mental health treatments might be heading and what needs to happen next.
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Lorna Staines discusses a recent Swedish cross-sectional study of 16,255 adolescent twins, which looks at the mental health risks of using psychedelics in the real world.
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Kirsten Lawson summarises a new ‘state of the art review’ in the BMJ which focuses on novel and emerging pharmacotherapy and neuromodulation for people with ‘treatment resistant depression’.
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In this blog, UCL MSc students consider an RCT published in the New England Journal of Medicine, which suggests that psilocybin-assisted psychotherapy may help reduce depression in people with severe and enduring illness, but side effects are common and more research is needed to look into longer term effects.
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In her debut blog, Heidi Stevens reviews a recent US randomised controlled trial on psilocybin-assisted psychotherapy for adults with alcohol use disorder, which leaves us with more questions than answers.
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Anya Borissova and Philip Brooks consider a recent review exploring MDMA-assisted psychotherapy and psilocybin-assisted psychotherapy for trauma-related mental health difficulties.
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James Rucker and Sameer Jauhar summarise a recent RCT on the effectiveness of psilocybin assisted therapy versus escitalopram assisted therapy for major depressive disorder.
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