Amphetamine-like stimulant use: what do we know about who uses them and how drug using careers develop?

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Harry Sumnall considers a systematic narrative review, which looks at the individual, social and environmental influences that shape key phases in the amphetamine-like stimulant use trajectory

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We know how to reduce premature deaths from co-morbid mental health and substance use problems, so why aren’t we doing anything about it?

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Ian Hamilton looks at a Swedish 42-year follow-up study, which looks at the impact that psychiatric comorbidity can have on premature death in a cohort of patients with substance use disorders.

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Psychosis during ADHD treatment with methylphenidate or amphetamines

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Samuele Cortese reports on a recent study of 13-25 year old people with ADHD, which looks at the comparative risk of psychosis during treatment with methylphenidate and amphetamines.

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Medication for ADHD: what works for adults, adolescents and children

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Dean Connolly is impressed by a recent systematic review and network meta-analysis, which compares the efficacy and tolerability of medication for ADHD in children, young people and adults.

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Amphetamines and methylphenidate for paediatric ADHD: meta-analysis of n-of-1 trials

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Samuele Cortese publishes his debut Mental Elf blog on a meta-analysis of n-of-1 trials, which shows that amphetamine derivatives and methylphenidate are superior to placebo, in the short term, for paediatric ADHD.

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Commonly prescribed psychiatric drugs: do they work?

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John Baker summarises a review of commonly prescribed medication that covers seven psychiatric drugs, including antidepressants, antipsychotics, benzodiazepines, amphetamines, methylphenidate and cholinesterase inhibitors.

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CBT for substance misuse in young people

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Eleanor Kennedy summarises a Campbell systematic review of CBT for substance misuse in young people in outpatient treatment, which is inconclusive in terms of CBT being more or less effective than other therapies.

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What is the relationship between eating disorders and crystal meth use?

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Epidemiological studies show that 50% of individuals with eating disorders abuse alcohol or illicit drugs, conversely up to 35% of those who abuse substances have eating disorders (ref: CASA report). Little is known about the association between eating disorders and methamphetamine (commonly known as crystal meth) use. Many methamphetamine users say that they take the [read the full story…]

New US care recommendations on the treatment of aggression in ADHD

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This care recommendation produced by Drew H. Barzman (Assistant Professor of Pediatrics and Psychiatry at Cincinnati Children’s Hospital Medical Center) sets out to answer the following question: Among children with ADHD and aggression, is the pharmacological treatment of ADHD, versus no pharmacological treatment of ADHD, effective in reducing aggressive behaviour? The authors searched Medline, PsychInfo, the National Guidelines [read the full story…]

Mixed amphetamine salts might be the best treatment to reduce ADHD symptoms in adults

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A new Cochrane review has found 7 randomised controlled trials that investigate the efficacy of amphetamine derivatives against placebo or an active intervention. Attention Deficit Hyperactivity Disorder (ADHD) is a childhood onset psychiatric disorder that can persist into adulthood in up to 50% of patients. From a clinical point of view, ADHD is characterized by hyperactivity, [read the full story…]