Targeting inflammation in depression: a proof-of-concept worth following

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A single dose of tocilizumab cleared inflammation in depressed patients, but did it ease their symptoms? A proof-of-concept RCT with cautious promise.

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Vitamin C, gut bacteria, and mental vitality: early findings

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In this small RCT, vitamin C supplementation improved attention and work absorption in healthy young adults with low vitamin C levels, alongside changes in gut bacteria and inflammation markers.

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Does the flu shot make you feel sick? What this randomised trial tells us about vaccine-induced inflammation

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Although a flu vaccine activated the immune system and raised cytokine levels in this randomised trial, participants didn’t feel substantially different from the placebo group. Vaccine models can help study subtle inflammation effects.

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When help feels out of reach: mental health and the menstrual cycle

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KCL MSc student Chiara Roux considers a survey study on help-seeking behaviours and experiences for mental health symptoms related to the menstrual cycle.

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“I’m always going to be tired”: fatigue in adolescent depression

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Georgia Kemp reflects on a recent qualitative paper that looks at adolescents’ personal accounts of fatigue as a symptom in depression.

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Psilocybin for ‘treatment-resistant depression’: an island of hope in an ocean of uncertainty?

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In this blog, UCL MSc students consider an RCT published in the New England Journal of Medicine, which suggests that psilocybin-assisted psychotherapy may help reduce depression in people with severe and enduring illness, but side effects are common and more research is needed to look into longer term effects.

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Adolescent depression is not the same as adult depression: new systematic review focuses on adolescents’ lived experiences

How are we currently supporting adolescents presenting with depression in clinical practice? Are we tailoring our approach, or are we treating them like mini adults?

Nina Higson-Sweeney reflects on the findings of a recent systematic review looking at the lived experience of adolescent depression, which has important implications for anyone supporting young people at risk of depression.

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Exercise therapy for chronic fatigue syndrome

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In this blog, Tracey Howe looks at a Cochrane systematic review, examining the effects of exercise therapy for patients with Chronic Fatigue Syndrome.

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