Antipsychotics for acute treatment of first episode schizophrenia

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Elwira Lubos writes her debut blog on a recent systematic review with pairwise and network meta-analyses, looking at antipsychotic drugs for the acute treatment of patients with first episode schizophrenia.

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Scaling and root planing adjuncts for chronic periodontitis

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In 2015 the American Dental Association published a Guideline on nonsurgical treatment of chronic periodontitis. This network meta-analysis re-analyses the included studies providing a complementary appraisal of the data.

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Third molar removal: effect on periodontal health of second mandibular molars

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Mark-Steven Howe looks in detail at a recent network meta-analysis (NMA) of periodontal outcomes following third molar surgery. However the limited number of studies available for the NMA mean the reviews findings need to be interpreted with caution.

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Can network meta-analysis decide the best psychosocial intervention for bipolar disorder?

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Guy Goodwin and Andrea Cipriani highlight a number of methodological concerns in a new network meta-analysis of psychosocial therapies for the adjunctive treatment of bipolar disorder.

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Anti-plaque agents: do they help reduce plaque levels?

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63 RCTs contributed to this network meta-analysis of the effectiveness of anti-plaque agents. Results suggested that toothpastes containing triclosan-copolymer or chlorhexidine and mouthrinses containing essential oils or chlorhexidine had the most effect on plaque indicies at 6 months.

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Time to stop prescribing antidepressants to young people with depression?

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Andrew Shepherd considers the implications of a recent network meta-analysis of the efficacy and tolerability of antidepressants for children and adolescents with depression.

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Antidepressants and psychotherapy for OCD in adults: network meta-analysis

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Alan Underwood summarises a recent network meta-analysis of medication and talking treatments for OCD (obsessive-compulsive disorder) in adults.

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Pharmacotherapy for smoking cessation in severe mental illness

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Andrew Jones reports on a recent systematic review and network meta-analysis of the efficacy and tolerability of pharmacotherapy for smoking cessation in severe mental illness, which finds a promising but low quality result for bupropion and varenicline.

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Antipsychotics for treatment-resistant schizophrenia

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Murtada Alsaif summarises a recent network meta-analysis, which looks at the efficacy, acceptability and tolerability of antipsychotics for treatment-resistant schizophrenia.

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IPT and CBT best for depression in children and young people, says network meta-analysis

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Laura Hemming summarises a recent network meta-analysis of psychotherapies for depression in children and young people, which finds that Interpersonal Psychotherapy (IPT) and Cognitive Behavioural Therapy (CBT) were significantly more efficacious than other psychotherapies at post-treatment and follow-up.

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