Antidepressants can help adults with major depression

thought-catalog-567751-unsplash

André Tomlin reports on a new network meta-analysis that brings together the best available evidence comparing the efficacy and acceptability of 21 antidepressants for the acute treatment of adults with major depressive disorder.

This groundbreaking review of 522 trials is the largest ever meta-analysis in psychiatry, and finds that antidepressants are more effective than placebo for short-term treatment of acute depression in adults.

[read the full story...]

Antipsychotics for acute treatment of first episode schizophrenia

Creative-Tail-medicine.svg

Elwira Lubos writes her debut blog on a recent systematic review with pairwise and network meta-analyses, looking at antipsychotic drugs for the acute treatment of patients with first episode schizophrenia.

[read the full story...]

Scaling and root planing adjuncts for chronic periodontitis

shutterstock_113989924  - periodontitis

In 2015 the American Dental Association published a Guideline on nonsurgical treatment of chronic periodontitis. This network meta-analysis re-analyses the included studies providing a complementary appraisal of the data.

[read the full story...]

Third molar removal: effect on periodontal health of second mandibular molars

shutterstock_133048361

Mark-Steven Howe looks in detail at a recent network meta-analysis (NMA) of periodontal outcomes following third molar surgery. However the limited number of studies available for the NMA mean the reviews findings need to be interpreted with caution.

[read the full story...]

Can network meta-analysis decide the best psychosocial intervention for bipolar disorder?

network-1246209_1280

Guy Goodwin and Andrea Cipriani highlight a number of methodological concerns in a new network meta-analysis of psychosocial therapies for the adjunctive treatment of bipolar disorder.

[read the full story...]

Anti-plaque agents: do they help reduce plaque levels?

shutterstock_87714310

63 RCTs contributed to this network meta-analysis of the effectiveness of anti-plaque agents. Results suggested that toothpastes containing triclosan-copolymer or chlorhexidine and mouthrinses containing essential oils or chlorhexidine had the most effect on plaque indicies at 6 months.

[read the full story...]

Time to stop prescribing antidepressants to young people with depression?

photo-1456397807017-5a6b47d257f4

Andrew Shepherd considers the implications of a recent network meta-analysis of the efficacy and tolerability of antidepressants for children and adolescents with depression.

[read the full story...]

Antidepressants and psychotherapy for OCD in adults: network meta-analysis

8463032564_da7e05776a_k

Alan Underwood summarises a recent network meta-analysis of medication and talking treatments for OCD (obsessive-compulsive disorder) in adults.

[read the full story...]

Pharmacotherapy for smoking cessation in severe mental illness

photo-1429035429336-ad854ea8a720

Andrew Jones reports on a recent systematic review and network meta-analysis of the efficacy and tolerability of pharmacotherapy for smoking cessation in severe mental illness, which finds a promising but low quality result for bupropion and varenicline.

[read the full story...]

Antipsychotics for treatment-resistant schizophrenia

4655344761_e526e9afff_b

Murtada Alsaif summarises a recent network meta-analysis, which looks at the efficacy, acceptability and tolerability of antipsychotics for treatment-resistant schizophrenia.

[read the full story...]