Medication for generalised anxiety disorder: new network meta-analysis

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A group of UCL Masters Students summarise a recent network meta-analysis of drug treatment for generalised anxiety disorder, which finds that Venlafaxine, Pregabalin, Escitalopram and Duloxetine are all viable alternatives to Benzodiazepines.

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Anti-plaque agents in toothpaste: Are they helpful in managing gingivitis?

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This review of the efficacy of different anti-plaque chemical agents in managing gingivitis included 32 RCTS of toothpastes and 19 of mouthrinses suggested greater benefits with some agents.

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Irreversible pulpitis: What is the most effective local anaesthetic for inferior alveolar nerve block?

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This review of the most effective anaesthetic solutions for inferior alveolar nerve blocks for mandibular teeth with irreversible pulpitis included 11 RCTs. The findings suggest that mepivacaine with epinephrine performed better than lidocaine with epinephrine but the number of trials is limited and the quality of evidence was very low to moderate.

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Medication for ADHD: what works for adults, adolescents and children

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Dean Connolly is impressed by a recent systematic review and network meta-analysis, which compares the efficacy and tolerability of medication for ADHD in children, young people and adults.

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Preventing psychosis: no one intervention is better than the rest

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A group of UCL Mental Health Masters students summarise a recent network meta-analysis that highlights a lack of evidence about specific interventions for preventing psychosis.

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Interdental cleaning aids

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This network meta-analysis of the comparative efficacy of interproximal oral hygiene aids included 22 RCTs and suggests that interdental brushes and water-jets ranked highest for the reduction of gingival bleeding. Although the quality of the available evidence is limited.

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Inferior Alveolar Nerve Block: improving anaesthetic success in patients with irreversible pulpitis

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This network meta-analysis of oral premedication to improve anaesthetic success of inferior alveolar nerve block in patients with irreversible pulpitis suggest that that oral premedication with dexamethasone, NSAIDs and Tramadol increases the success rate.

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Antidepressants can help adults with major depression

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André Tomlin reports on a new network meta-analysis that brings together the best available evidence comparing the efficacy and acceptability of 21 antidepressants for the acute treatment of adults with major depressive disorder.

This groundbreaking review of 522 trials is the largest ever meta-analysis in psychiatry, and finds that antidepressants are more effective than placebo for short-term treatment of acute depression in adults.

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Antipsychotics for acute treatment of first episode schizophrenia

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Elwira Lubos writes her debut blog on a recent systematic review with pairwise and network meta-analyses, looking at antipsychotic drugs for the acute treatment of patients with first episode schizophrenia.

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Scaling and root planing adjuncts for chronic periodontitis

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In 2015 the American Dental Association published a Guideline on nonsurgical treatment of chronic periodontitis. This network meta-analysis re-analyses the included studies providing a complementary appraisal of the data.

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