Alexandra Pike, Alexis An Yee Low and Jonathan Roiser critically appraise a recent n-of-1 study on ‘brain pacemakers for depression’, which received extensive press coverage earlier this month. The case study looks at deep brain stimulation (closed-loop neuromodulation) in an individual with treatment-resistant depression.
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Anya Borissova summarises a recent randomised placebo-controlled trial that evaluated ketamine metabolites, clinical response, and gamma power for major depression.
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James Rucker and Sameer Jauhar summarise a recent RCT on the effectiveness of psilocybin assisted therapy versus escitalopram assisted therapy for major depressive disorder.
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In her debut blog, Harmony Jiang reviews a recent qualitative study exploring patients’ experience and response to ketamine treatment for depression.
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Anya Borissova summarises the therapeutic mechanisms of psilocybin in treatment-resistant depression and changes noticed in the amygdala and prefrontal cortex during emotional processing.
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Pascal Immanuel Michael summarises a recent RCT, which looks at how a single dose of the psychedelic Ayahuasca may help people with severe depression who have not benefited from more traditional treatment.
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Jodi Rintelman writes her debut elf blog on the first randomised controlled trial on the efficacy and safety of intranasal esketamine as an adjunctive treatment to antidepressants for treatment-resistant depression.
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Jessica Bone reports on a recent cross-sectional study that looks at the clinical correlates of augmentation/combination treatment strategies in major depressive disorder.
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Our #EvidenceLive team of bloggers report on a recent feasibility study of psilocybin for the treatment of refractory depression.
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Sarah McDonald reports on a meta-analysis published yesterday, which found that when compared with active treatment, mindfulness-based cognitive therapy resulted in a reduced risk of depressive relapse.
This blog also features a podcast interview with the lead author of the research, Professor Willem Kuyken.
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