Turn on, or tune out? Is psilocybin assisted therapy close to becoming a first-line treatment for depression?

reproductive-health-supplies-coalition-V4pVBEHKPo0-unsplash

James Rucker and Sameer Jauhar summarise a recent RCT on the effectiveness of psilocybin assisted therapy versus escitalopram assisted therapy for major depressive disorder.

[read the full story...]

Patients’ experience of ketamine treatment for depression: the ‘Ketamine and me’ project

shutterstock_562050361

In her debut blog, Harmony Jiang reviews a recent qualitative study exploring patients’ experience and response to ketamine treatment for depression.

[read the full story...]

Psilocybin for treatment-resistant depression: what are the effects on brain activity?

bret-kavanaugh-_af0_qAh4K4-unsplash

Anya Borissova summarises the therapeutic mechanisms of psilocybin in treatment-resistant depression and changes noticed in the amygdala and prefrontal cortex during emotional processing.

[read the full story...]

Ayahuasca-induced increases in brain-derived neurotrophic factor (BNDF) associated with reduced depression

28603239812_e87b743a04_k

Pascal Immanuel Michael summarises a recent RCT, which looks at how a single dose of the psychedelic Ayahuasca may help people with severe depression who have not benefited from more traditional treatment.

[read the full story...]

Intranasal esketamine for treatment-resistant depression: the first clinical study

shutterstock_174166007

Jodi Rintelman writes her debut elf blog on the first randomised controlled trial on the efficacy and safety of intranasal esketamine as an adjunctive treatment to antidepressants for treatment-resistant depression.

[read the full story...]

Polypharmacy for major depression: is practice evidence-based?

joshua-coleman-623077-unsplash

Jessica Bone reports on a recent cross-sectional study that looks at the clinical correlates of augmentation/combination treatment strategies in major depressive disorder.

[read the full story...]

Magic mushrooms promising for treatment resistant depression

Psilocybin

Our #EvidenceLive team of bloggers report on a recent feasibility study of psilocybin for the treatment of refractory depression.

[read the full story...]

Mindfulness-based cognitive therapy can prevent recurrent depression

702361266_359e089599_b

Sarah McDonald reports on a meta-analysis published yesterday, which found that when compared with active treatment, mindfulness-based cognitive therapy resulted in a reduced risk of depressive relapse.

This blog also features a podcast interview with the lead author of the research, Professor Willem Kuyken.

[read the full story...]

Long-term psychoanalytic psychotherapy for treatment-resistant depression

psychology-531071_1280

Sarah McDonald presents the results of the Tavistock Adult Depression Study; a pragmatic RCT of long-term psychoanalytic psychotherapy for treatment-resistant depression.

[read the full story...]

Cognitive therapies for depression in adults: let’s just stick to the facts

6810854382_27c644f059_h

Ioana Cristea reviews the NIHR-DC Highlight on cognitive therapies for depression, published online today, which summarises three NIHR-funded trials (REEACT, CoBalT and PREVENT) looking at cCBT, CBT and MBCT for depression in adults.

[read the full story...]