Slow-release fluoride devices for caries prevention: insufficient evidence


This review of slow-release fluoride devices for caries prevention updates an earlier Cochrane review of the topic. However no new trials have been identified providing insufficient evidence to assess their effectiveness.

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Periodontitis- supportive periodontal treatment


This Cochrane review of the effects of supportive periodontal therapy (SPT) in the maintenance of the dentition of adults treated for periodontitis included 4 RCTs providing is insufficient evidence to determine the superiority of different protocols or adjunctive strategies to improve tooth maintenance during SPT.

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Opiate substitution therapy: supervised-consumption vs take-home doses


Vicky Carlisle publishes her debut elf blog on a Cochrane review of supervised dosing with long-acting opioid medication in the management of opioid dependence.

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Metal-free fixed dental prosthesis – insufficient evidence to support or refute effectiveness


Only 9 small RCTs were included in this Cochrane review of metal-free materials for prosthodontic restorations providing insufficient evidence to support or refute the effectiveness of metal-free materials for fixed prosthodontic treatment over metal-ceramic or other type of standard restorations.

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Mucositis in adult cancer patients reduced with keratinocyte growth factor


This Cochrane review of cytokines and growth factors for preventing oral mucositis in patients having cancer treatment included 35 RCTs finding keratinocyte growth factor beneficial in the prevention of oral mucositis .

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Antipsychotic combinations for schizophrenia: safe and effective?


Elena Marcus presents the findings of an updated Cochrane review on antipsychotic combinations for schizophrenia.

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Fluoride supplements for pregnant women to prevent caries in their children

Pregnancy is a major life changing event for all women, but this study shows that women who are depressed during pregnancy are also at risk of reduced breastfeeding initiation and premature delivery

This Cochrane review of fluoride supplements during pregnancy for the prevention of caries in their children identified only a single trial which provided no evidence of caries prevention in their offspring.

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Orthodontic treatment for Class II division 2 malocclusion: No randomised trial evidence


This Cochrane review of orthodontic treatment for class II div 2 malocclusion updates the previous 2006 version. No RCTs or CCTs were identified so It is not possible to provide any evidence-based guidance to recommend or discourage any type of orthodontic treatment to correct Class II division 2 malocclusion in children.

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Drugs to prevent salivary gland damage following radiotherapy to the head and neck

This Cochrane review of drugs for the prevention of radiation-induced salivary gland dysfunction included 39 studies, while a range of agents was tested the evidence found is not sufficient to highlight much promise in terms of effective preventative treatments.

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Fissure sealants effective in preventing caries in children and adolescents

Fissure sealant

38 trials were included in this updated Cochrane review of the effect of fissure sealants on occlusal caries. The data show a reduction in caries of between 11-51% at 24months compared to no sealant. The benefit was also maintained at longer-term follow up.

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