Drugs to prevent salivary gland damage following radiotherapy to the head and neck

This Cochrane review of drugs for the prevention of radiation-induced salivary gland dysfunction included 39 studies, while a range of agents was tested the evidence found is not sufficient to highlight much promise in terms of effective preventative treatments.

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Fissure sealants effective in preventing caries in children and adolescents

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38 trials were included in this updated Cochrane review of the effect of fissure sealants on occlusal caries. The data show a reduction in caries of between 11-51% at 24months compared to no sealant. The benefit was also maintained at longer-term follow up.

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Periodontal treatment during pregnancy-no evidence of impact on preterm birth

Routine specialist pregnancy care involved an initial meeting to discuss quitting smoking and set a quit date, followed by 4 weekly telephone calls, and free nicotine replacement therapy for 10 weeks.

15 RCTs were included in this Cochrane review of impact of periodontal treatment on adverse pregnancy outcomes. all the included studies were considered to be at high risk of bias. There was no evidence that periodontal treatment reduces the number of preterm babies.

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Occlusal caries prevention: Seal or varnish?

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This large, well-conducted study in a primary care setting found a small, but not statistically significant difference, between fissure sealants and fluoride varnish for the prevention of caries in first permanent molars at 36 months.

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Chlorhexidine mouthrinse: Reduced plaque and gingivitis when used as adjunct to mechanical oral hygiene procedures

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51 studies were included in this Cochrane review of chlorhexidine mouthwash as an adjunct to mechanical oral hygiene measures. The review provides high quality evidence for a large reduction in the build-up of plaque at 4 to 6 weeks or 6 months. There is also high quality evidence of a moderate reduction in gingivitis in patients with mild gingivitis which may not be clinically important.

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Cochrane find insufficient evidence to support the implementation of depression prevention programmes

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Ioana Cristea summarises the latest Cochrane review on CBT, third-wave CBT and IPT based interventions for preventing depression in children and adolescents

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Risperidone versus placebo for people with schizophrenia

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Joanne Wallace summarises the recent Cochrane systematic review on risperidone versus placebo for schizophrenia, which concludes that the best available evidence does not show that the benefits of risperidone outweigh the harms.

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Pain during orthodontic treatment: non-pharmacological interventions

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14 trials were included in this Cochrane review of non-pharmacological interventions for orthodontic pain. The findings were inconclusive although there is some evidence that low-level laser therapy may help.

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Retrograde root filling: insufficient evidence for best material

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The Cochrane review of of materials for retrograde root filling identified 6 RCTs all at high risk of bias. The trials provide insufficient evidence to draw any conclusion as to the benefits of any one material over another so more high quality studies are needed.

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Root canal treatment: single or multiple visits?

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This Cochrane review update included 25 RCTs comparing single verses multiple root canal treatment approaches. They found no evidence to suggest that one treatment regimen is better than the other.

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