Peri-implantitis: Are locally administered antibiotics effective?

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This review of the effectiveness of locally administered antibiotics in the treatment of peri-implantitis included 12 small studies 7 of which were RCTs. While the findings suggest a small additional benefit with antibiotic use however the clinical importance of this is debatable.

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Tooth loss in diabetic patients

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This review assessing the risk of losing teeth among patients with diabetes mellitus (DM) compared to those without DM included 10 studies the majority of which were cross-sectional (80%). While the findings suggest higher risk of tooth loss in patients with diabetes the findings should be viewed cautiously.

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Diabetes and periodontal status in children and adolescents

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This review comparing the periodontal status of normal children with those living with diabetes regardless of type included 11 studies. While the findings suggest that children and adolescents with diabetes have poorer periodontal status the quality of the evidence is low.

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Periodontal disease: Does it increase risk of Alzheimer’s disease and mild cognitive impairment?

Participants who reported higher levels of depression and social isolation had greater risk of loneliness, along with people living alone with dementia.

This blog on a review evaluating the association between periodontal disease (PD), Alzheimer’s disease (AD) and mild cognitive impairment (MCI) was written by the Scottish Special Care StRs following a critical appraisal workshop. The review included 13 studies and suggests a link between PD and AD/MCI, but the evidence is limited.

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Tooth loss during long-term periodontal maintenance

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This review evaluating risk factors / predictors of tooth loss in patients with periodontitis having periodontal therapy and long-term periodontal maintenance (PM) included 33 studies only 3 of which were prospective. There findings suggest that patients having long-term PM suffer the loss of 1 tooth per patient every 10 years.

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Probiotics and gingival inflammation

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This review of the effect of probiotics on gingival inflammation and oral microbiota in patients suffering from plaque-induced gingivitis included 11 RCTs. No clear evidence was found to indicate that oral probiotics have a positive effect on gingival inflammation and oral microecological environment of patients with gingivitis.

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Clarithromycin as an adjunct to non-surgical periodontal treatment

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This review of systemic or locally delivered clarithromycin as an adjunct to non-surgical periodontal therapy included 7 small RCTs, 4 RCTS related to systemic use and 3RCTS for local application. The findings provide moderate certainty evidence suggesting locally delivered clarithromycin significantly improves treatment outcome

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Rubber bristles interdental cleaners as an adjunct to toothbrushing

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This review of the efficacy of rubber bristles interdental cleaners (RBIC) as an adjunct to toothbrushing (TB) included 6 RCTs. The findings provide weak to very weak certainty evidence for the use of RBICs for gingivitis and plaque reduction.

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Curcumin mouthwashes for plaque and gingivitis

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This review of the efficacy of curcumin mouthwash on plaque and gingivitis in comparison with chlorhexidine included 6 RCTs. While the findings suggest that curcumin mouthwashes have promising anti-plaque and anti-gingivitis properties 5 of the 6 studies were at high risk of bias.

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Chronic periodontitis: Efficacy of adjunctive antimicrobials

Many drugs are licensed for use in Generalised Anxiety Disorder (GAD), but it is unclear what works best.

This review of the efficacy of antimicrobials adjunctive to scaling and root planing (SRP) in the treatment of chronic periodontitis. 21 RCTs were included with the findings showing that amoxicillin and metronidazole had the largest statistical benefit. Whether this benefit is a clinically important benefit is a wider question.

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