Periodontal infrabony defects: does autologous platelet concentrates (APC) improve surgical outcomes

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38 RCTs were included in this Cochrane review of the effects of autologous platelet concentrates (APC) used as an adjunct to periodontal surgery. Very low quality evidence was found for two approaches involving open flap debridement.

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Statins as an adjunct to periodontal treatment?

This well conducted Cochrane review found no evidence that statins

This review of the adjunctive effect of statins on mechanical periodontal therapy included 15 studies 12 of which were RCTs. The findings suggest a positive effect on probing pocket depth, clinical attachment level, and intrabony defects but the overall quality of evidence is considered to be low.

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Non-surgical periodontal therapy – which antibiotic regime?

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This review of amoxicillin & metronidazole as an adjunct to non-surgical periodontal treatment included 18 trials . A small benefit was seen with antibiotic use but no clinically meaningful difference between different doses or duration of amoxicillin-plus-metronidazole at 3 months post-treatment.

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Phytotherapy as an adjunct to nonsurgical periodontal treatment?

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7 small RCTs that majority of cross-over design were included in this review of phytotherapy as an adjunct to scaling and root planing for chronic periodontitis. While the findings suggest a benefit these should be viewed with caution until results from larger high quality studies are available.

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Intrabony periodontal defects – does combining bone substitutes and enamel matrix derivatives improve outcomes?

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This review of combining bone substitutes and enamel matrix derivatives for the management of intrabony periodontal defects only identified 5 small RCTs of limited quality. The addition of EMD to bony substitutes was not seen to be beneficial but the results should be interpreted cautiously due to limitations in the available evidence.

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Statins as an adjunct to scaling and root planing

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11 RCTs were included in this review of statins as an adjunct to scaling and root planing. The findings suggest improvements in pocket depth and clinical attachment levels with statin use.

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Scaling and root planing: Do adjunctive statins improve effectiveness?

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10 randomised trials were included in this review of he adjunctive use of statins with scaling and root planing for treatment of chronic periodontitis . The findings suggest additional benefits with their use regardless of health or smoking status.

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Khat chewing has an adverse effect on periodontal tissues

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12 observational studies were included in this review of the effect of khat chewing on periodontal tissues. The available evidence is of limited quality but it suggests that khat use has an adverse effect on periodontal status.

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Periodontal maintenance after specialist treatment: specialist or primary care setting?

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This reviews of the efficacy of periodontal maintenance treatment carried out in primary care compared to the specialist setting following specialist treatment included 8 cohort studies. The quality of the available evidence was limited suggesting outcomes may be poorer in primary care further high quality studies are required

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Periodontal regeneration therapies: Are benefits long-term?

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This review of periodontal regeneration therapies included 52 trials. While the results suggest some statistically significant improvements they may not be clinically important. There is also limited data for outcomes longer than 12 months.

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