Chronic periodontitis: pocket elimination after osseous resective surgery

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4 RCTs involving 96 patients were included in this review of osseous resective surgery (ORS) in the treatment of residual periodontal defects.
The findings suggest some benefit from ORS but they should be interpreted cautiously because of the limited number of small studies.

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Antiseptics as adjuncts to nonsurgical periodontal treatment

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This review of the effectiveness of adjunctive local antiseptics to conventional scaling and root planning (SRP) included 12 RCTs only 3 of whihc were considered to be at low risk of bias. While the findings suggest some benefit from the use of antiseptics with a sustained-release delivery the limited quality of the included studies means that the findings should be interpreted cautiously.

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Chlorhexidine gel as an adjunct to non-surgical periodontal treatment

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This review of the efficacy of adjunctive subgingival administration of chlorhexidine gel in nonsurgical periodontal treatment for chronic periodontitis included 17 RCTs only one of which was at low risk of bias for all domains. Findings suggest an improvement in pocket probing depth but not for clinical attachment.

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Periodontal surgery: Is a minimally invasive approach effective for infrabony defects?

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This review of minimally invasive periodontal surgery for the treatment of intra‐bony defects included 25 studies of which 10 were randomised controlled trials. There is limitied evidence comparing minimal and traditional approach but minimal invasive surgery may produce similar outcomes.

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Mesenchymal stem cells in periodontal regeneration?

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This review evaluating the potential efficacy of mesenchymal stem cells in periodontal regeneration included 15 small studies of very low quality. Additional high quality RCTs are neeeded to assess effectiveness before clinicial use.

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Hyaluronic acid as an adjunct to periodontal treatment

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This review looked at the adjunctive effects of hyaluronic acid (HA) on surgical or non-surgical periodontal treatment. Thirteen RCTs the majority at high risk of bias suggested that the topical application of HA may lead to additional clinical benefits.

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Tooth loss predictors in periodontal patients

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This review of predictors of tooth loss in patients with periodontitis undergoing treatment and receiving supportive care included 20 studies. Findings suggest older, non‐compliant patients, smokers, diabetics, those with IL‐1‐polymorphism, and teeth with bone loss, high probing pocket depths, mobility, as well as molars, especially with furcation involvement, are at higher risk of tooth loss.

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Periodontal infrabony defects: does autologous platelet concentrates (APC) improve surgical outcomes

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38 RCTs were included in this Cochrane review of the effects of autologous platelet concentrates (APC) used as an adjunct to periodontal surgery. Very low quality evidence was found for two approaches involving open flap debridement.

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Statins as an adjunct to periodontal treatment?

This well conducted Cochrane review found no evidence that statins

This review of the adjunctive effect of statins on mechanical periodontal therapy included 15 studies 12 of which were RCTs. The findings suggest a positive effect on probing pocket depth, clinical attachment level, and intrabony defects but the overall quality of evidence is considered to be low.

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Non-surgical periodontal therapy – which antibiotic regime?

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This review of amoxicillin & metronidazole as an adjunct to non-surgical periodontal treatment included 18 trials . A small benefit was seen with antibiotic use but no clinically meaningful difference between different doses or duration of amoxicillin-plus-metronidazole at 3 months post-treatment.

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