This review evaluating the potential efficacy of mesenchymal stem cells in periodontal regeneration included 15 small studies of very low quality. Additional high quality RCTs are neeeded to assess effectiveness before clinicial use.
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This review looked at the adjunctive effects of hyaluronic acid (HA) on surgical or non-surgical periodontal treatment. Thirteen RCTs the majority at high risk of bias suggested that the topical application of HA may lead to additional clinical benefits.
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This review of the efficacy of scaling and root planning (SRP) and SRP + adjuvant treatments in improving glycaemic control in patients with type 2 diabetes mellitus and chronic periodontitis included 14 RCTs suggesting some benefit in the short term.
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This review of predictors of tooth loss in patients with periodontitis undergoing treatment and receiving supportive care included 20 studies. Findings suggest older, non‐compliant patients, smokers, diabetics, those with IL‐1‐polymorphism, and teeth with bone loss, high probing pocket depths, mobility, as well as molars, especially with furcation involvement, are at higher risk of tooth loss.
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This review of the efficacy of aloe vera mouthrinse on plaque and gingival inflammation includes 6 RCTS providing very low quality evidence that aloe vera mouthwash is comparable to chlorhexidine in reducing gingival inflammation.
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Two UK primary care-based trials were included in this Cochrane review update of routine scale and polish. They provide high certainty evidence of litte or no difference between 6- & 12-monthly scale and polish for adult regular attenders without severe periodontitis.
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38 RCTs were included in this Cochrane review of the effects of autologous platelet concentrates (APC) used as an adjunct to periodontal surgery. Very low quality evidence was found for two approaches involving open flap debridement.
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91 diabetic patients were randomised to non-surgical scaling and root planing and amoxicillin or control. While periodontal status significantly improved at 3 months there was no no significant effects on
glycaemic control.
This Cochrane review of the efficacy of different root coverage procedures for gingival recession included 48 RCTs describing a range of procedures. Most procedures led to a reduction in gingival recession.
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This review of the effectiveness of regenerative periodontal treatment for preventing periodontal defects following third molar surgery included 21 RCTs and suggested that these approaches were effective. However a majority of the included studies were at high risk of bias so the findings should be interpreted cautiously.
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