Two small RCTs at high risk of bias were included in this Cochrane systematic review looking at the effects of periodontal therapy for primary or secondary prevention of CVD in people with chronic periodontitis.
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This review of minimally invasive periodontal surgery for the treatment of intra‐bony defects included 25 studies of which 10 were randomised controlled trials. There is limitied evidence comparing minimal and traditional approach but minimal invasive surgery may produce similar outcomes.
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This review evaluating the potential efficacy of mesenchymal stem cells in periodontal regeneration included 15 small studies of very low quality. Additional high quality RCTs are neeeded to assess effectiveness before clinicial use.
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This review looked at the adjunctive effects of hyaluronic acid (HA) on surgical or non-surgical periodontal treatment. Thirteen RCTs the majority at high risk of bias suggested that the topical application of HA may lead to additional clinical benefits.
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This review of the efficacy of scaling and root planning (SRP) and SRP + adjuvant treatments in improving glycaemic control in patients with type 2 diabetes mellitus and chronic periodontitis included 14 RCTs suggesting some benefit in the short term.
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This review of predictors of tooth loss in patients with periodontitis undergoing treatment and receiving supportive care included 20 studies. Findings suggest older, non‐compliant patients, smokers, diabetics, those with IL‐1‐polymorphism, and teeth with bone loss, high probing pocket depths, mobility, as well as molars, especially with furcation involvement, are at higher risk of tooth loss.
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This review of the efficacy of aloe vera mouthrinse on plaque and gingival inflammation includes 6 RCTS providing very low quality evidence that aloe vera mouthwash is comparable to chlorhexidine in reducing gingival inflammation.
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Two UK primary care-based trials were included in this Cochrane review update of routine scale and polish. They provide high certainty evidence of litte or no difference between 6- & 12-monthly scale and polish for adult regular attenders without severe periodontitis.
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38 RCTs were included in this Cochrane review of the effects of autologous platelet concentrates (APC) used as an adjunct to periodontal surgery. Very low quality evidence was found for two approaches involving open flap debridement.
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91 diabetic patients were randomised to non-surgical scaling and root planing and amoxicillin or control. While periodontal status significantly improved at 3 months there was no no significant effects on
glycaemic control.
