Can we predict and prevent weight gain in early psychosis?

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New research suggests that weight gained in the first 12 weeks of antipsychotic treatment is the biggest driver of long-term obesity in psychosis.

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Stop, reduce or stay on antipsychotics after first-episode psychosis?

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Once symptoms stabilise after a first episode of psychosis, should medication continue? A four-year RCT explores the risks and rewards of dose reduction.

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Age-at-migration and ethnicity may increase psychosis risk

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Sueda Coskun reflects on a recent case control study with data from five European countries, which suggests that migration during adolescence may be a particular risk factor for developing psychosis.

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Cognition and heterogeneity in first-episode psychosis before antipsychotic treatment

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Ana Veic looks at an updated systematic review which suggests that patients with psychosis display cognitive difficulties very early in the disease process, and concludes this variation in cognitive function should prompt individual clinical assessments to optimise care.

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Lived experience perspectives of acceptance and commitment therapy for people with psychosis

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Charlotte Huggett reflects on a qualitative study exploring the perspectives of people with psychosis receiving Acceptance and Commitment Therapy following a first episode of psychosis.

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Early intervention for psychosis: better outcomes in the short term?

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Emanuele Osimo blogs about the 20-year follow up of the OPUS trial, which tested early intervention services for people with first-episode schizophrenia spectrum disorder.

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Neuroimaging abnormalities in first-episode psychosis: clinically-relevant or not?

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Joe Pierre considers a systematic review and meta-analysis on the prevalence of neuroimaging abnormalities in first-episode psychosis and the clinical relevance for service users presenting with first-episode psychosis.

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Predicting treatment-resistant psychosis using routine clinical measures

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Lorna Staines summarises a recent study on predicting treatment-resistant psychosis, which suggests that future risk prediction efforts should seek to consider routinely collected data.

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What’s the relationship between stressful life events and psychosis?

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Kris Deering considers a 2-year prospective observational study published in the Lancet Psychiatry which found strong links between stressful life events and relapse in first-episode psychosis.

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Where I lay my head is home: residential instability and earlier onset of psychosis

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Liana Romaniuk summarises a recent US cross-sectional study which suggests that residential instability (moving home a lot) may lead to disrupted social networks and relationships, predisposing vulnerable youth to greater stress, which can increase their risk of psychosis.

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