The genetic link behind sleep problems, cognitive dysfunction, and neuroticism in ‘treatment-resistant depression’

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A big new study suggests that certain genetic traits—like insomnia risk and neuroticism—may make depression harder to treat, while protective traits include education and cognitive ability.

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Closing the care gap: Why so few people with mental disorders receive effective treatment worldwide

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Effective treatment for mental health disorders remains the exception rather than the rule. A new 21-country study reveals where in the treatment cascade people are most likely to drop out and which factors improve the odds of getting the care they need.

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Do psychiatric disorder genes overlap with their drug targets? And does this matter?

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Psychiatric disorders are highly heritable, but are the genes we identify in GWAS the same ones our medications target? This new study digs into the overlap and raises questions about how we develop treatments.

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GLP-1 receptor agonists and the brain: could these medications boost more than metabolism?

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GLP1 drugs are already used to treat diabetes and support weight loss, but do they have any impact on mental health? This new meta-analysis looks at the evidence from 80 clinical trials.

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Collaborative care for depression: what are the key components?

Collaborative care is a complex intervention for chronic disease that has been shown to be significantly more effective for depression than usual care. Yet, implementation in routine practice is rare.

Despite strong evidence, collaborative care remains underused in the NHS. This blog explores new findings that highlight which components of the model are most effective in reducing depression symptoms.

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One therapy, many disorders: the strengths and limitations of CBT across mental health conditions

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CBT is a cornerstone of mental health care, but how well does it really work across different disorders? This massive new meta-analysis offers some answers and raises new questions.

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What’s in the blood? Immune cell changes in schizophrenia

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Dr Fabiana Corsi-Zuelli discusses the differences in immune cell counts in patients with schizophrenia compared to controls; highlighting a recent meta-analysis by Dudeck et al. (2025) that reinforces the growing consensus that immune dysfunction plays a role in schizophrenia.

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Global insights into youth mental health prevalence: challenges and future directions

While the use of a global dataset allows for cross-regional comparisons, there is limited data from low- and middle-income countries, alongside underrepresentation from high-risk groups.

Shuwen Su, a MSc Global Mental Health student from the University of Glasgow, summarises an epidemiological study that estimates the global prevalence and years lived with disability associated with mental health disorders and substance use disorders in young people aged 5-24 years old.

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The other side of postnatal depression: what about Dads?

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Demetra Christodoulou reviews a new randomised controlled trial from Pakistan testing “Learning Through Play Plus Dads”: a group parenting programme designed to support fathers with postnatal depression.

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Patterns of inflammation in childhood and mental and cardiometabolic disorders in adulthood: mapping the trajectories

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Ruby Tsang summarises a recent longitudinal study of trajectories of inflammation in youth and risk of mental and cardiometabolic disorders in adulthood, which finds that high levels of inflammation in childhood may be linked to an increased risk of psychosis, depression and insulin resistance in early adulthood.

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