Desensitising toothpastes for dentine hypersensitivity a network meta-analysis

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This network meta-analysis comparing the effect of different desensitising toothpastes on dentine hypersensitivity included 30 RCTs. The findings suggest that toothpastes containing nano-hydroxyapatite or arginine may be the most effective. However additional larger studies are required.

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High fluoride toothpaste for arresting and preventing root caries

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This randomised trial comparing 5000ppm fluoride tootpaste v 1450ppm paste in adults aged 60 and above demonstrated fewer new root canal lesions in the 5000ppm group at 2 years.

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Fluoride toothpaste: Effects of different fluoride concentrations on caries

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This Cochrane review of effectiveness of different fluoride concentrations of toothpaste in reducing dental caries updates the 2010 review and includes 96 RCTs. It provideds good evidence to support the benefits of using fluoride toothpaste in preventing caries and demonstrates a does response effect.

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Toothbrushing: fluoride toothpaste needed to reduce caries

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Three RCTs were included in this review of the association between personal oral hygiene and coronal dental caries. The findings suggest that in the absence of fluorides personal oral hygiene did not reduce the incidence of caries.

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Caries prevention in young children: topical fluoride alone not sufficient suggests trial

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This large trial investigated the use of a ‘preventive package’ of fluoride varnish, fluoride toothpaste, toothbrush and standard dental health education in children between 2-3 years attending general practice. The intervention did not keep young children caries free but did reduce caries levels.

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White spot lesions: available treatments may provide improvements

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This review of treatments for post orthodontic white spot lesions included 20 studies examining a wide variety of approaches. Modest benefits were seen in addition to daily use of fluoride toothpaste and furhter high quality studies are needed to identify the best approaches.

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Toothpaste and plaque removal

Plaque off, Fluoride on. Brushing your teeth really is that simple.
Image: Adam Drewes (CC BY-NC-SA 2.0)

This review of the efficacy of brushing with and without a toothpaste for plaque removal identified 10 trials involving a total of 444 patients. While the results suggest no differences other reviews have demonstrated clear oral health benefits from brushing with toothpaste.

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Arginine and caries prevention

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7 RCTs were included in this review of the caries prevention effects of arginine containing dental products. They provide insufficient evidence to support a caries preventive effect for arginine in toothpaste.

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Arginine in combination with calcium bases and fluoride in toothpaste may be better than fluoride alone

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Ten trials were included in this review of arginine in toothpaste. It found that arginine in combination with calcium bases (either Dical or calcium carbonate) and fluoride provided a superior effect compared with fluoride alone. However, 9 out of 10 of the trials were sponsored by a single company and the overall quality of the evidence was considered to be low.

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Xylitol in toothpaste may provide small additional benefit over fluoride toothpastes

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This Cochrane review included 10 studies and found low quality evidence that fluoride toothpaste containing xylitol may be more effective than fluoride-only toothpaste for preventing caries in the permanent teeth. The evidence for other xylitol products is insufficient to assess effectiveness.

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