This network meta-analysis comparing the effect of different desensitising toothpastes on dentine hypersensitivity included 30 RCTs. The findings suggest that toothpastes containing nano-hydroxyapatite or arginine may be the most effective. However additional larger studies are required.
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Inês Pote summarises a recent meta-analysis of randomised placebo-controlled trials of cognitive behavioural therapy for anxiety and related disorders.
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This network meta-analysis of oral premedication to improve anaesthetic success of inferior alveolar nerve block in patients with irreversible pulpitis suggest that that oral premedication with dexamethasone, NSAIDs and Tramadol increases the success rate.
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Students and Teachers from the King’s College London PNoMH Distance Learning MSc summarise a major new meta-analysis that brings together the last 60 years of placebo-controlled antipsychotic drug trials in acute schizophrenia.
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André Tomlin reports on a new network meta-analysis that brings together the best available evidence comparing the efficacy and acceptability of 21 antidepressants for the acute treatment of adults with major depressive disorder.
This groundbreaking review of 522 trials is the largest ever meta-analysis in psychiatry, and finds that antidepressants are more effective than placebo for short-term treatment of acute depression in adults.
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This review of the effectiveness of silver diamine fluoride (SDF) in arresting caries included 11 studies with 4 contributing to a meta-analysis showing it to be more effective than other active agents and placebo.
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10 RCTs were included in this update of a Cochrane review of interventions for the management of patients with taste disturbances. VEry low quality evidence suggest that zinc supplementation my be beneficial but further high quality research is needed.
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Natalie Nelissen from mHabitat publishes her debut elf blog on a recent systematic review of mental health apps for young people, which highlights the current dearth of reliable research to support the efficacy and safety of mobile apps.
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Murtada Alsaif considers a recent systematic review on the safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an atypical antipsychotic in acute bipolar depression.
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Joanne Wallace summarises the recent Cochrane systematic review on risperidone versus placebo for schizophrenia, which concludes that the best available evidence does not show that the benefits of risperidone outweigh the harms.
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