When the treatment doesn’t work: what predicts difficult-to-treat postpartum depression?

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Swedish nationwide study of 58,618 women found 6% experienced treatment-resistant postpartum depression. Risk factors included lower socioeconomic status, smoking, pre-existing health conditions, caesarean or preterm birth.

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Can crisis planning reduce repeat sectioning? FINCH feasibility trial

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FINCH trial of 80 people showed crisis planning intervention was feasible to deliver in NHS settings. Results leaned towards fewer repeat detentions, but study not designed to prove effectiveness.

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Metformin reduces weight gain in young people taking antipsychotics

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Large pragmatic trial found metformin plus lifestyle intervention reduced weight gain in young people with bipolar disorder taking antipsychotics. Effect significant but modest at 6 and 24 months.

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Do prescribed opioids increase self-harm and suicide?

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Study of 3 million Australian adults prescribed opioids, 84% of self-harm events and 81% of suicides didn’t involve opioids. Challenges belief that prescribing increases self-harm risk.

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Changing sleep patterns linked to cognitive decline and dementia

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Two large cohorts (one UK, one Chinese) found shifting from optimal to non-optimal sleep or stopping napping linked to higher dementia risk. But reverse causation limits certainty about prevention.

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Can compassion focused therapy groups support people in CMHTs?

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Small service evaluation of compassion-focused therapy groups in two CMHTs found some participants improved on self-compassion and depression measures. Findings preliminary, not evidence of effectiveness.

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Embedding psychologists in trauma centres improves patient outcomes

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First evaluation of specialist psychology in NHS Major Trauma Centre finds psychologists improve recovery outcomes and support frontline staff facing emotional toll.

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Growing up hungry: food insecurity’s lasting impact on eating

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Children who experienced food insecurity in early childhood had higher odds of binge eating and compensatory behaviours in adolescence, even when food insecurity resolved.

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Carrying heavy secrets alone: sexual trauma disclosure in boys and men

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Boys and men take 15-20 years on average to disclose sexual trauma. Masculine norms, shame, and fear of disbelief create unique barriers to help-seeking.

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Shared genetic patterns found across 14 psychiatric disorders

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Psychiatric disorders share genetic variants that cluster into five main factors. Understanding shared biology could improve treatment, but more diverse genetic data urgently needed.

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