Do antipsychotics slow down thinking? New evidence from healthy volunteers

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New research reveals how antipsychotic medications affect working memory speed in healthy adults, providing crucial insights into the cognitive side effects of these widely prescribed drugs.

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Should you start metformin whenever you start antipsychotics?

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Guidelines say metformin can help prevent weight gain from antipsychotics like olanzapine, but this large UK study shows it’s rarely prescribed. What’s stopping us?

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Lithium is best at decreasing the risk of depression-related hospitalisation in bipolar disorder, according to new cohort study

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This Swedish cohort study, blogged by Duncan Swiffen, is yet more evidence for lithium as an excellent treatment for people with bipolar disorder. This time it comes out on top in terms of preventing depression-related hospitalisation.

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Just how good are antipsychotics at preventing relapse? Bridging the efficacy-effectiveness gap

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Samei Huda summarises a new network meta-analysis in the Lancet Psychiatry on the efficacy and effectiveness of antipsychotics for schizophrenia in research settings, such as randomised controlled trials, versus real-world and clinical settings.

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Youth mental health interventions: umbrella review presents efficacy and acceptability data

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In his debut blog, Nick Meader tackles a huge umbrella review of youth mental health interventions, which presents the efficacy and acceptability of 72 different approaches to help children and young people.

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Risperidone and aripiprazole: genotype, metabolism and dosage

CYP2D6 genotyping before starting treatment might be valuable in clinical practice for individualising risperidone and aripiprazole treatment.

Dolly Sud writes her debut elf blog on a recent retrospective analysis, which compares dose changes of risperidone and aripiprazole with patients’ individual genotype.

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Sexual function matters to people living with serious mental illness

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Rudiger Pittrof and Elana Covshoff from SHRINE (Sexual and Reproductive Health Rights, Inclusion and Empowerment) explore a recent review, which looks at the impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management.

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Antidepressants for depression in schizophrenia: when good-enough evidence is good enough

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Carmine Pariante is positive about a recent systematic review and meta-analysis of antidepressants for the treatment of depression in schizophrenia.

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Schizophrenia, antipsychotics and quality of life: measuring the important things

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Samei Huda mulls over a recent RCT on the effects of older and newer antipsychotics on quality of life in schizophrenia. The study finds a different result to the 10-year old CUTLASS trial; namely that second generation antipsychotics may be superior to first generation antipsychotics in terms of improving quality of life for people with schizophrenia.

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Aripiprazole for treatment-resistant depression in older adults

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Sarsha Wilson publishes her debut blog about a recent RCT on the efficacy, safety and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in later life.

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