bipolar disorder

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Introduction

Bipolar, otherwise known as manic depression, now exists largely within common consciousness and understanding, thanks to high profile stigma-busting publicity.

Characterised by episodic shifts in a person’s mood (between manic and depressed states), as well as their energy and activity levels, which can significantly impact their daily functioning, bipolar is estimated to affect 1% of the population across the lifetime. However, this figure rises to over 4% if you include those who experience more than one episode of sub-threshold manic (or ‘hypomanic’) symptoms.

What we know already

Anxiety is unsurprisingly common in people living with bipolar. Similarly, substance abuse is frequently reported.

Whilst there is no cure, there are several well-established treatment options. Bipolar is usually treated using mood-stabiliser, atypical anti-psychotic and/or antidepressant medications, alongside psychological, and diet and lifestyle interventions. We know, for example, that bipolar can be well managed using regular monitoring of mood, keeping stress levels to a minimum, and ensuring good sleep.

Areas of uncertainty 

Like many mental health difficulties, the precise causes of bipolar are unknown, though they are likely multi-faceted. Research shows that you are more likely to develop bipolar if it exists in your family. Although most children with such circumstances will not go on to develop bipolar, there appears to be a strong genetic component. Environmental factors such as stressful life events are also thought to play an important role.

Recent research suggests that, whilst it appears beneficial to treat bipolar with psychological interventions, the heterogeneity of the evidence makes it difficult to decide which treatments (such as CBT, Mindfulness etc) work best.

What’s in the pipeline?

Large-scale studies, such as the U.S-based Bipolar Disorder Phenome Database, are seeking to better understand the complex genetic picture.

Advances in brain imaging will no doubt provide rich information regarding the neurochemical and neurostructural profile of bipolar. Similarly, technological advances are enabling more sophisticated ways of promoting self-management in conditions such as bipolar.

References

Merikangas, K.R., Akiskal, H.S., Angst, J., et al. (2007) Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Archives of General Psychiatry, 64, 543-552. [Abstract]

Stratford, H.J., Cooper, M.J., Di Simplicio, M., Blackwell, S.E. and Holmes, E.A. (2015) Psychological therapy for anxiety in bipolar spectrum disorders: a systematic review. Clinical Psychology Review, 35, 19-34. [Abstract]

Acknowledgement

Written by: Patrick Kennedy-Williams
Reviewed by:
Last updated: Sep 2015
Review due: Sep 2016

Our bipolar disorder Blogs

Do psychiatric disorder genes overlap with their drug targets? And does this matter?

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Psychiatric disorders are highly heritable, but are the genes we identify in GWAS the same ones our medications target? This new study digs into the overlap and raises questions about how we develop treatments.

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Feeding the mind: early signs that keto could help with bipolar disorder

Emerging research into the effects of a ketogenic diet have reported neuroprotective and anti-inflammatory mechanisms along with a positive metabolic effect

This pilot study explored how a ketogenic diet affects mood, metabolic health, and brain chemistry in people with bipolar disorder. The results are early, but they offer food for thought.

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Unravelling bipolar disorder: insights from the biggest genetic study to date

Bipolar disorder is a leading contributor to the global burden of disease with significant impact on quality of life, functioning and suicide risk.

A massive new multi-ancestry genetic study of bipolar disorder has uncovered hundreds of risk loci and highlighted biological pathways that may guide more precise treatments and prevention strategies in the future.

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Increased risk of respiratory disease in bipolar means it’s time to breathe new life into physical healthcare

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Risk of respiratory disease is greatly heightened for people with bipolar disorder but we are missing opportunities to intervene to improve lung health.

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Can sleep and activity changes really predict mania in bipolar disorder?

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Alyson Dodd reports on a year long study of digital mood monitoring in people with bipolar disorder, which suggests that sleep and activity changes precede hypomanic episodes by three days. This data could be a useful clinical tool, but more research is needed.

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Probiotics for bipolar disorder and schizophrenia

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Mary Butler explores a recent randomised controlled trial of probiotic formulations for patients with bipolar disorder or schizophrenia spectrum disorder.

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We need to improve sleep assessment and treatment in patients with severe mental illness

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Emiliana Tonini looks at how sleep is recorded and treated in people with serious mental illness—and how it affects their engagement with services. The study finds that sleep is rarely part of routine clinical assessment, and recommended sleep treatments are hardly ever used.

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Lithium is best at decreasing the risk of depression-related hospitalisation in bipolar disorder, according to new cohort study

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This Swedish cohort study, blogged by Duncan Swiffen, is yet more evidence for lithium as an excellent treatment for people with bipolar disorder. This time it comes out on top in terms of preventing depression-related hospitalisation.

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Uncharted territory: cumulative trauma and bipolar disorder

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Magda Skowronska summarises a recent systematic review which finds that cumulative trauma could lead to earlier onset of bipolar disorder. A review that has important implications for mental health professionals.

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