Chlorhexidine mouthrinse: Reduced plaque and gingivitis when used as adjunct to mechanical oral hygiene procedures

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51 studies were included in this Cochrane review of chlorhexidine mouthwash as an adjunct to mechanical oral hygiene measures. The review provides high quality evidence for a large reduction in the build-up of plaque at 4 to 6 weeks or 6 months. There is also high quality evidence of a moderate reduction in gingivitis in patients with mild gingivitis which may not be clinically important.

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Oral mucositis in cancer patients: no benefit from chlorhexidine mouthwash

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This review of chlorhexidine (CHX) for prevention & treatment of oral mucositis included 12 RCTs with 9 contribution to the meta-analysis. CHX was not significantly effective in preventing mucositis or reducing its severity.

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Tranexamic acid for minor oral surgery in anticoagulated patients

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5 good but small RCTs were identified for this review of topical tranexamic acid (TXA) for minor oral surgery in patients on anticoagulants. The findings suggest that TXA irrigation and mouthwash may reduce the risk of bleeding.

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Dentine hypersensitivity: do mouthwashes help?

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This review of mouthwashes for the management of dentine hypersensitivity included 7 small studies all at high risk of bias. While minor benefits in patients’ subjective perception were seen the limited quality of the study means these findings should be interpreted with caution.

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Anti-plaque agents: do they help reduce plaque levels?

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63 RCTs contributed to this network meta-analysis of the effectiveness of anti-plaque agents. Results suggested that toothpastes containing triclosan-copolymer or chlorhexidine and mouthrinses containing essential oils or chlorhexidine had the most effect on plaque indicies at 6 months.

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Essential oils mouthwash reduced plaque and gingival inflammation

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This review of essential oils mouthwashes included 16 RCTs and found them to be more effective for the reduction of plaque and gingival inflammation than mechanical plaque control either alone (placebo) or in combination with mouthwashes with CPC.

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High frequency or prolonged use of mouthwash increased risk of head and neck cancer

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This study from the INHANCE collaboration pooled data from 12 case-controlled studies. Long-term use (35 yrs) of mouthwash was associated with an increase risk OR=1.15 (95%CI; 1.01 to 1.30) of head and neck cancer but with regular (>2 x daily), long-term (>35 years) use OR = 1.75 (95%CI; 1.25 to 2.48).

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Neem-based mouthwash –little evidence available

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This review of the effectiveness of neem-based mouthwash for improving plaque control and gingival health only identified 3 low quality RCTs of short duration providing little evidence to assess its effectiveness.

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Mouthwashes and toothpastes can improve oral malodour

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This review identified 12 trials of mouthwashes and toothpastes for oral malodour. Those products with active ingredients reduced oral malodour but the overall quality of the available evidence was weak.

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Gingivitis: anti-plaque agents may help

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This new review covers the board topic of the efficacy of anti-plaque chemical formulations for managing gingivitis. 87 heterogeneous studies found a statistically significant benefit with most test products.

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