Brain scans, depression, and AI: small signals, big questions

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A new study uses AI on brain scans to predict depression. The findings are modest, but the implications go beyond the hospital.

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Internet-delivered CBT for depression: real-world evidence shows similar benefits to face-to-face therapy

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This Finnish study of 5,834 healthcare records found therapist-guided internet CBT showed similar depression improvements to face-to-face therapy, providing real-world evidence beyond selective RCT populations.

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Inside the diagnostic grey zone: using machine learning to separate bipolar and major depression

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High misdiagnosis rates between bipolar and major depressive disorder cause real harm to patients and services. This new neuroimaging study tested whether brain connectivity and machine learning could do a better job of telling the two apart, with interesting but limited results.

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Spotting the storm before it breaks: mapping the prodrome of severe mental illness

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People with severe mental illness often face years of poor health before diagnosis. A new study uses machine learning and clinical notes to map the early warning networks of symptoms that could help us intervene earlier.

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Predicting antidepressant response using artificial intelligence

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Holly Fraser discusses new findings on whether and how we can predict antidepressant response using artificial intelligence.

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Genetic risk for schizophrenia is associated with changes in heart structure and function

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Nadine Parker and Ole Andreassen summarise a recent UK population-based cohort study, which looks at the impact of polygenic risk for schizophrenia on cardiac structure and function in over 32,000 people.

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Stratified care versus stepped care for depression: which is more effective?

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Sarah Watts reviews a cluster randomised clinical trial investigating the effectiveness of stratified care compared to stepped care for depression, which has implications for IAPT services.

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Mental health stigma and online social support for bipolar disorder: what can we learn from Twitter?

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Charlotte Walker explores an online ethnography study that explores how Twitter users discuss mental illness, particularly bipolar disorder, and in what context; focusing specifically on the areas of stigma and social support.

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Predicting suicide attempts in adolescents: machine learning is powerful, but don’t forget Bayes’ rule

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Derek de Beurs explores a recent study that uses longitudinal clinical data and machine learning to predict suicide attempts in adolescents.

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Can a machine learning approach help us predict what specific treatments work best for individuals with depression?

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Marcus Munafo explores a recent study that uses a machine learning approach across two trials (STARD*D and CO-MED) to try and predict treatment outcomes (primarily focusing on the antidepressant citalopram) for depression.

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