Predicting treatment-resistant psychosis using routine clinical measures

diego-ph-fIq0tET6llw-unsplash

Lorna Staines summarises a recent study on predicting treatment-resistant psychosis, which suggests that future risk prediction efforts should seek to consider routinely collected data.

[read the full story...]

Antipsychotics for acute treatment of first episode schizophrenia

Creative-Tail-medicine.svg

Elwira Lubos writes her debut blog on a recent systematic review with pairwise and network meta-analyses, looking at antipsychotic drugs for the acute treatment of patients with first episode schizophrenia.

[read the full story...]

Antipsychotics for treatment-resistant schizophrenia

4655344761_e526e9afff_b

Murtada Alsaif summarises a recent network meta-analysis, which looks at the efficacy, acceptability and tolerability of antipsychotics for treatment-resistant schizophrenia.

[read the full story...]

Lost in anxiety: treatment-resistant anxiety in older people

shutterstock_219436936

Andrés Fonseca appraises a new systematic review of interventions for treatment-resistant anxiety in older people, which finds a disconcerting lack of evidence to help him support the many older patients he sees who are affected by anxiety disorders.

[read the full story...]

Lithium is less expensive than olanzapine in treatment-resistant depression, but has unclear clinical benefits

shutterstock_148197704

Treatment-resistant depression (TRD) still represents a challenge to psychiatric practice. Since patients have usually failed at least two antidepressants, drugs originally prescribed for other conditions are often tried as an augmentation (Souery er al., 2006). Amongst them, lithium (a mood-stabiliser used in the treatment of bipolar disorders) as well as atypical antipsychotics (AAPs, indicated for [read the full story…]

Largest RCT so far suggests that ketamine may be useful in the acute treatment of refractory depression

shutterstock_137892476

Major depression is a serious mental illness that often does not respond to mainstream drug treatment (antidepressants). In addition, there is usually a delay of 2-6 weeks before mood improves significantly. In situations like this, when at least two conventional antidepressants have been tried without success, depression is considered treatment-resistant. While multiple different strategies to [read the full story…]

Depressed patients who respond poorly to antidepressants are significantly more likely to develop bipolar disorder, says new cohort study

shutterstock_85649404

Bipolar disorder is a complex health condition and the diagnosis of bipolar depression is a fairly contentious topic. This is because depression occurs in bipolar disorder alongside a wide range of symptoms of mood elevation. Some patients have depressive episodes as well as severely elevated mood during the course of their illness, whereas other patients [read the full story…]