Antidepressants and psychotherapy for adolescent depression: can they be compared? #ActiveIngredientsMH

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Catherine Harmer summarises a recent network meta-analysis relating to her own Wellcome Trust funded research into antidepressants for young people with anxiety or depression.

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In adults with major depression, antidepressants may increase the risk of suicide

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Douglas Badenoch explores a meta-analysis of follow-up data from clinical trials of antidepressants, which found a small but significant increase in suicide risk.

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Off-label antidepressants: limited evidence to support their use

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John Baker reports on Canadian study looking at prescriptions of off-label antidepressants in primary care, which concludes that when antidepressants were used outside of their licence, there was usually not strong evidence supporting the respective indication.

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Antidepressants: benefits and harms in children and adults

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Samei Huda discusses the findings of a recent review into suicidality and aggression during antidepressant treatment. The systematic review and meta-analyses were based on clinical study reports and included some important adverse effects of antidepressants in children and young people.

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