Inferior Alveolar Nerve Block: improving anaesthetic success in patients with irreversible pulpitis

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This network meta-analysis of oral premedication to improve anaesthetic success of inferior alveolar nerve block in patients with irreversible pulpitis suggest that that oral premedication with dexamethasone, NSAIDs and Tramadol increases the success rate.

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Non-medical use of prescription drugs #NonMedicalDrugs

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Ian Hamilton and Julia Buxton from the University of York preview the #NonMedicalDrugs event that will take place in York on Friday 16th March 2018.

The meeting will bring together people who can offer personal and professional insights of the extent of the issue and how we can support people who develop problems.

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Opiate substitution therapy: supervised-consumption vs take-home doses

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Vicky Carlisle publishes her debut elf blog on a Cochrane review of supervised dosing with long-acting opioid medication in the management of opioid dependence.

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Few adverse events with single dose oral analgesics for acute postoperative pain

This overview of adverse event rates associated with single dose oral analgesics includes data from 39 Cochrane reviews, and provides evidence that adverse events rates are generally similar with active drug and placebo.

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Impaired inhibitory control in addiction

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Maartje Luijten, Assistant Professor at the Behavioural Science Institute at Radboud University, writes her debut blog on a recent meta-analysis of deficits in behavioural inhibition in substance abuse and addiction.

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How does buprenorphine fair as an alternative to methadone for treating opioid dependence?

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Meg Fluharty summarises a recent Cochrane review, which tells us that high-dose buprenorphine is an effective maintenance treatment for heroin compared to placebo, but fixed flexible-dosing methadone is superior to buprenorphine at participant retention.

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Illegal drug use during pregnancy is associated with a host of complications for both Mother and baby

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The potential dangers of illegal drug use are never far from the media spotlight, and drug use during pregnancy may be associated with particular health problems both for the Mother and baby. Drug use during pregnancy has been linked with a number of negative outcomes, for example, cocaine use has been linked with an increased [read the full story…]

Is it safe to prescribe benzodiazepines and opioids together?

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Benzodiazepines are most commonly prescribed for the management of anxiety and insomnia. They can also be used for sedation or amnesia before medical or surgical procedures, treatment of seizure, treatment of alcohol or sedative withdrawal, or acute agitation. Known side effects include drowsiness, fatigue and ataxia (the loss of full control of bodily movements). Opioids [read the full story…]