Anti-inflammatories for depression: targeting the right patients matters

feat

Decades of disappointing anti-inflammatory trials for depression may have failed because they weren’t targeting the right patients. New meta-analysis shows promising results when they do.

[read the full story...]

Anticholinergics are associated with worse cognition: it’s time to take a serious look at our prescribing

A lot of pills in a pile

Eleanor Dawkins explores a new review and meta-analysis suggesting that cognitive impairment is linked with anticholinergic medication in psychosis, providing grounds for more careful monitoring and review of medications.

[read the full story...]

HRT associated with reduced risk of psychosis relapse in middle-age women

Close,Up,Head,And,Shoulders,View,Of,Older,Woman,In

Laura Naysmith summarises a study of menopausal hormone therapy (also known as HRT), which suggests the treatment is linked with reduce the risk of psychosis relapse in menopausal women.

[read the full story...]

Jury remains out on antidepressant-induced mania, despite findings of Danish trial emulation

nastya-dulhiier-x2cooe_MaG8-unsplash

Michael Kalfas and Paul Leeks summarise a recent Danish study that assesses the risk of antidepressant-induced mania in patients with bipolar depression.

[read the full story...]

Predicting antidepressant response using artificial intelligence

Ai,Brain,Implant,Discovery,Concept,Collage,Art.,Young,Male,Person

Holly Fraser discusses new findings on whether and how we can predict antidepressant response using artificial intelligence.

[read the full story...]

Tackling structural racism in suicide prevention: a conceptual framework

African-american,Male,In,Black,T-shirt,On,Gray,Isolated,Background

Kam Bhui reviews a conceptual framework developed to understand structural racism and suicide prevention for ethnoracially minoritised youth in the United States.

[read the full story...]

Violent behaviour by people diagnosed with psychosis: what is good evidence?

shutterstock_519626059

Vishal Bhavsar reviews a recent study examining correlates of future violent behaviour in people being treated for schizophrenia in US-based treatment centres.

[read the full story...]

Cognitive functioning in psychosis: is neuropsychological decline continuous, generalised, and specific to schizophrenia?

shutterstock_1466819675

Emmeline Lagunes Cordoba and Derek Tracy explore a case control study that looks at cognitive change in people with schizophrenia and other psychoses in the decade following the first episode.

[read the full story...]

Lamotrigine for “Borderline Personality Disorder”: should we prescribe it? #BIGSPD19

charisse-kenion-1417690-unsplash

Keir Harding prepares for the #BIGSPD19 conference by reading Mike Crawford et al’s recent RCT on the clinical effectiveness and cost-effectiveness of lamotrigine in borderline personality disorder.

[read the full story...]

Can smoking cessation improve cognitive functioning in people with psychosis?

diego-lopez-770963-unsplash

Dafni Katsampa explores a recent prospective cohort study that investigates the association between smoking behaviour and cognitive functioning in patients with psychosis, their siblings and healthy control subjects.

[read the full story...]